B6.Cg-Ptprca Trp53inp1tm1Acar/Orl

Status

Available to order

EMMA IDEM:06223
International strain nameB6.Cg-Ptprca Trp53inp1tm1Acar/Orl
Alternative nameTP53INP1 KO Ly5.1
Strain typeSpontaneous
Allele/Transgene symbolPtprca,
Gene/Transgene symbolPtprc

Information from provider

ProviderAlice Carrier
Provider affiliationInserm U1068 / CRCM
Genetic informationNull mutation of Trp53inp1 gene.
Phenotypic informationMouse model of chronic oxidative stress promoting cancer development.
Breeding historyWe already described the breeding history in our previous submissions of this KO mutation on C57BL/6 and 129/Sv background (EMMA strain ID EM:02038). For the present submission on Ly5.1 (Ptprca, or CD45 Ly5.1 allele), we have crossed homozygous KO on C57BL/6 (Ly5.2) background with wild-type Ly5.1 mice to obtain homozygous KO Ly5.1 in two steps. Those mice are mandatory to perform competitive bone-marrow reconstitution experiments.
References
  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209
  • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.;Gironella Meritxell, Seux Mylène, Xie Min-Jue, Cano Carla, Tomasini Richard, Gommeaux Julien, Garcia Stephane, Nowak Jonathan, Yeung Man Lung, Jeang Kuan-Teh, Chaix Amandine, Fazli Ladan, Motoo Yoshiharu, Wang Qing, Rocchi Palma, Russo Antonio, Gleave Martin, Dagorn Jean-Charles, Iovanna Juan L, Carrier Alice, Pébusque Marie-Josèphe, Dusetti Nelson J, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;16170-5; 17911264
  • Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.;Cano Carla E, Gommeaux Julien, Pietri Sylvia, Culcasi Marcel, Garcia Stéphane, Seux Mylène, Barelier Sarah, Vasseur Sophie, Spoto Rose P, Pébusque Marie-Josèphe, Dusetti Nelson J, Iovanna Juan L, Carrier Alice, ;2009;Cancer research;69;219-26; 19118006
  • Mutant mouse models of oxidative stress.;Pouyet Laurent, Carrier Alice, ;2010;Transgenic research;19;155-64; 19662508
  • TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.;Seux M, Peuget S, Montero M P, Siret C, Rigot V, Clerc P, Gigoux V, Pellegrino E, Pouyet L, N'Guessan P, Garcia S, Dufresne M, Iovanna J L, Carrier A, André F, Dusetti N J, ;2011;Oncogene;30;3049-61; 21339733
  • Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis.;N'guessan Prudence, Pouyet Laurent, Gosset Gaëlle, Hamlaoui Sonia, Seillier Marion, Cano Carla E, Seux Mylène, Stocker Pierre, Culcasi Marcel, Iovanna Juan L, Dusetti Nelson J, Pietri Sylvia, Carrier Alice, ;2011;Antioxidants & redox signaling;15;1639-53; 21235351
  • TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.;Seillier M, Peuget S, Gayet O, Gauthier C, N'Guessan P, Monte M, Carrier A, Iovanna J L, Dusetti N J, ;2012;Cell death and differentiation;19;1525-35; 22421968
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, homozygous C57BL/6J
Breeding at archiving centreTo restore the right phenotype with the frozen sperm users should use C57BL/6-Ly5.1 (Ptprc-a) females for the IVF. Embryos have been obtained crossing males and females of the Trp53inp1-KO L5.1 (Ptprc-a) line so they all have the right genotype.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal cell morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased body weight / MGI
  • hyperglycemia / MGI
  • neoplasm / MGI
  • increased colonic adenoma incidence / MGI
  • increased circulating insulin level / MGI
  • hepatic steatosis / MGI
  • increased liver weight / MGI
  • large intestinal inflammation / MGI
  • oxidative stress / MGI
  • increased incidence of tumors by chemical induction / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • increased susceptibility to weight gain / MGI
  • increased susceptibility to diet-induced obesity / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal epididymal fat pad morphology / MGI
  • increased susceptibility to induced colitis / MGI
  • abnormal renal fat pad morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal respiratory electron transport chain / MGI
  • abnormal oxidative phosphorylation / MGI
  • increased mitochondria number / MGI
  • abnormal mitophagy / MGI
  • increased body fat mass / MGI
  • increased susceptibility to diet-induced non-insulin dependent diabetes / MGI

Literature references

  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209
  • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.;Gironella Meritxell, Seux Mylène, Xie Min-Jue, Cano Carla, Tomasini Richard, Gommeaux Julien, Garcia Stephane, Nowak Jonathan, Yeung Man Lung, Jeang Kuan-Teh, Chaix Amandine, Fazli Ladan, Motoo Yoshiharu, Wang Qing, Rocchi Palma, Russo Antonio, Gleave Martin, Dagorn Jean-Charles, Iovanna Juan L, Carrier Alice, Pébusque Marie-Josèphe, Dusetti Nelson J, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;16170-5; 17911264
  • Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.;Cano Carla E, Gommeaux Julien, Pietri Sylvia, Culcasi Marcel, Garcia Stéphane, Seux Mylène, Barelier Sarah, Vasseur Sophie, Spoto Rose P, Pébusque Marie-Josèphe, Dusetti Nelson J, Iovanna Juan L, Carrier Alice, ;2009;Cancer research;69;219-26; 19118006
  • Mutant mouse models of oxidative stress.;Pouyet Laurent, Carrier Alice, ;2010;Transgenic research;19;155-64; 19662508
  • TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.;Seux M, Peuget S, Montero M P, Siret C, Rigot V, Clerc P, Gigoux V, Pellegrino E, Pouyet L, N'Guessan P, Garcia S, Dufresne M, Iovanna J L, Carrier A, André F, Dusetti N J, ;2011;Oncogene;30;3049-61; 21339733
  • Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis.;N'guessan Prudence, Pouyet Laurent, Gosset Gaëlle, Hamlaoui Sonia, Seillier Marion, Cano Carla E, Seux Mylène, Stocker Pierre, Culcasi Marcel, Iovanna Juan L, Dusetti Nelson J, Pietri Sylvia, Carrier Alice, ;2011;Antioxidants & redox signaling;15;1639-53; 21235351
  • TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.;Seillier M, Peuget S, Gayet O, Gauthier C, N'Guessan P, Monte M, Carrier A, Iovanna J L, Dusetti N J, ;2012;Cell death and differentiation;19;1525-35; 22421968

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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