B6D2-Tg(Gnrhr-ALPP)1Jnl/Orl
| Status | Available to order |
| EMMA ID | EM:06297 |
| International strain name | B6D2-Tg(Gnrhr-ALPP)1Jnl/Orl |
| Alternative name | Tg(Gnrhr-ALPP)1Jnl |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Gnrhr-ALPP)1Jnl |
| Gene/Transgene symbol | Tg(Gnrhr-ALPP)1Jnl |
Information from provider
| Provider | Jean-Noël Laverriere |
| Provider affiliation | Biologie fonctionnelle et adaptative Paris7-CNRS EAC 4413, Université Paris Diderot |
| Genetic information | This transgene directs the expression of human ALPP gene reporter under the control of rat 3.3 Kbp Gnrhr promoter to specific sites of Gnrhr gene expression (gonadotropic cells in the pituitary and other extra-pituitary sites such as hippocampus, lateral septum, amygdala, retina and pineal). |
| Phenotypic information | Transgene insertion does not induce noticeable phenotype. Specific alkaline placental phosphatase activity can be detected at specific sites of Gnrhr gene expression. |
| Breeding history | More than 50 generations of inbreeding. Current breed: inbred cross of littermate mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6 x DBA/2 |
Literature references
- The promoter of the rat gonadotropin-releasing hormone receptor gene directs the expression of the human placental alkaline phosphatase reporter gene in gonadotrope cells in the anterior pituitary gland as well as in multiple extrapituitary tissues.;Granger Anne, Ngô-Muller Valérie, Bleux Christian, Guigon Céline, Pincas Hanna, Magre Solange, Daegelen Dominique, Tixier-Vidal Andrée, Counis Raymond, Laverrière Jean-Noël, ;2004;Endocrinology;145;983-93; 14592958
- The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter.;Granger Anne, Bleux Christian, Kottler Marie-Laure, Rhodes Simon J, Counis Raymond, Laverrière Jean-Noël, ;2006;Molecular endocrinology (Baltimore, Md.);20;2093-108; 16613990
- GnRH receptor gene expression in the developing rat hippocampus: transcriptional regulation and potential roles in neuronal plasticity.;Schang Anne-Laure, Ngô-Muller Valérie, Bleux Christian, Granger Anne, Chenut Marie-Claude, Loudes Catherine, Magre Solange, Counis Raymond, Cohen-Tannoudji Joëlle, Laverrière Jean-Noël, ;2011;Endocrinology;152;568-80; 21123436
- Identification and analysis of two novel sites of rat GnRH receptor gene promoter activity: the pineal gland and retina.;Schang Anne-Laure, Bleux Christian, Chenut Marie-Claude, Ngô-Muller Valérie, Quérat Bruno, Jeanny Jean-Claude, Counis Raymond, Cohen-Tannoudji Joëlle, Laverrière Jean-Noël, ;2013;Neuroendocrinology;97;115-31; 22414758