IMPC phenotypes (gene matching)
C57BL/6N-Atp2a2tm1a(EUCOMM)Hmgu/H
| Status | Available to order |
| EMMA ID | EM:06358 |
| Citation information | RRID:IMSR_EM:06358 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Atp2a2tm1a(EUCOMM)Hmgu/H |
| Alternative name | HEPD0714_3_B04 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Atp2a2tm1a(EUCOMM)Hmgu |
| Gene/Transgene symbol | Atp2a2 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0714_3_B04. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Acrokeratosis verruciformis of Hopf / Orphanet_79151
- Darier disease / Orphanet_218
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal heart shape / MGI
- esophageal epithelium hyperplasia / MGI
- toenail hyperkeratosis / MGI
- hyperkeratosis / MGI
- decreased body weight / MGI
- impaired righting response / MGI
- cardiac hypertrophy / MGI
- decreased embryo size / MGI
- decreased litter size / MGI
- increased tumor incidence / MGI
- increased skin papilloma incidence / MGI
- premature death / MGI
- abnormal blood circulation / MGI
- heart left ventricle hypertrophy / MGI
- dilated heart left ventricle / MGI
- dilated heart right ventricle / MGI
- increased heart weight / MGI
- decreased systemic arterial blood pressure / MGI
- fatigue / MGI
- thick ventricular wall / MGI
- cardiac fibrosis / MGI
- increased esophageal papilloma incidence / MGI
- abnormal locomotor activation / MGI
- aorta coarctation / MGI
- abnormal vascular endothelial cell migration / MGI
- abnormal physiological neovascularization / MGI
- increased left ventricle diastolic pressure / MGI
- decreased left ventricle systolic pressure / MGI
- pulmonary edema / MGI
- abnormal vascular endothelial cell physiology / MGI
- abnormal cardiac muscle relaxation / MGI
- increased squamous cell carcinoma incidence / MGI
- abnormal calcium ion homeostasis / MGI
- increased response of heart to induced stress / MGI
- decreased cardiac muscle contractility / MGI
- cachexia / MGI
- bradykinesia / MGI
- lethargy / MGI
- stomach epithelial hyperplasia / MGI
- decreased ventricle muscle contractility / MGI
- decreased angiogenesis / MGI
- cardiac interstitial fibrosis / MGI
- congestive heart failure / MGI
- abnormal osteoclast differentiation / MGI
- penis prolapse / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- ventricular septal defect / MGI
- atrial septal defect / MGI
- ascending aorta hypoplasia / MGI
- thin ventricle myocardium compact layer / MGI
- neonatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- increased tongue papilloma incidence / MGI