IMPC phenotypes (gene matching)
B6.129P2-Lcn2tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06368 |
| Citation information | RRID:IMSR_EM:06368 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Lcn2tm1Mak/Cnbc |
| Alternative name | Lcn 2 C57Bl 6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lcn2tm1Mak |
| Gene/Transgene symbol | Lcn2 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Lipocalin 2, Targeted (knock-out), Insertion, Intragenic deletion |
| Phenotypic information | Iron-trafficking protein involved in multiple processes such as innate immunity and cancer development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous males |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased brown adipose tissue amount / MGI
- increased white adipose tissue amount / MGI
- increased circulating LDL cholesterol level / MGI
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- abnormal erythropoiesis / MGI
- increased bone marrow cell number / MGI
- spleen hyperplasia / MGI
- thymus hyperplasia / MGI
- abnormal myelopoiesis / MGI
- reduced female fertility / MGI
- increased circulating insulin level / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal mast cell physiology / MGI
- increased hematocrit / MGI
- hepatic steatosis / MGI
- increased heart weight / MGI
- increased liver weight / MGI
- no phenotypic analysis / MGI
- increased erythrocyte cell number / MGI
- increased erythroid progenitor cell number / MGI
- thrombocytopenia / MGI
- increased kidney weight / MGI
- decreased adiponectin level / MGI
- increased spleen weight / MGI
- increased lymphocyte cell number / MGI
- increased B cell number / MGI
- sepsis / MGI
- increased circulating cholesterol level / MGI
- impaired glucose tolerance / MGI
- insulin resistance / MGI
- renal/urinary system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased macrophage cell number / MGI
- increased mean corpuscular hemoglobin / MGI
- increased susceptibility to diet-induced obesity / MGI
- decreased apoptosis / MGI
- increased fat cell size / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased splenocyte number / MGI
- increased liver triglyceride level / MGI
- decreased thymocyte apoptosis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- myeloid hyperplasia / MGI
- impaired adaptive thermogenesis / MGI
- increased erythroblast number / MGI
- increased fasted circulating glucose level / MGI
Literature references
- Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.;Berger Thorsten, Togawa Atsushi, Duncan Gordon S, Elia Andrew J, You-Ten Annick, Wakeham Andrew, Fong Hannah E H, Cheung Carol C, Mak Tak W, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;1834-9; 16446425
- Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.;Berger Thorsten, Cheung Carol C, Elia Andrew J, Mak Tak W, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;2995-3000; 20133630