IMPC phenotypes (gene matching)
B6.129P2-Flot2tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06369 |
| Citation information | RRID:IMSR_EM:06369 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Flot2tm1Mak/Cnbc |
| Alternative name | Flot 2 C57Bl 6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Flot2tm1Mak |
| Gene/Transgene symbol | Flot2 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Targeted mutation (intragenic deletion) in the Flot2 gene. |
| Phenotypic information | Flot2 deficiency leads to reduction in lung metastasis formation in the MMTV - PyMT mouse breast cancer model. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury.;Berger Thorsten, Togawa Atsushi, Duncan Gordon S, Elia Andrew J, You-Ten Annick, Wakeham Andrew, Fong Hannah E H, Cheung Carol C, Mak Tak W, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;1834-9; 16446425
- Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.;Berger Thorsten, Cheung Carol C, Elia Andrew J, Mak Tak W, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;2995-3000; 20133630