C57BL/6NTac-Zscan10^{tm2a(EUCOMM)Wtsi}/WtsiCnrm

Status	Available to order
EMMA ID	EM:06375
Citation information	RRID:IMSR_EM:06375 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Zscan10^{tm2a(EUCOMM)Wtsi}/WtsiCnrm
Alternative name	EPD0157_1_B07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Zscan10^{tm2a(EUCOMM)Wtsi}
Gene/Transgene symbol	Zscan10
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0157_1_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

IMPC phenotypes (allele matching)

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

decreased circulating calcium level / MGI
decreased body weight / MGI
microphthalmia / MGI
abnormal lens morphology / MGI
cataract / MGI
hyperactivity / MGI
hypoactivity / MGI
impaired coordination / MGI
increased startle reflex / MGI
reduced female fertility / MGI
abnormal vision / MGI
increased mean platelet volume / MGI
decreased circulating corticosterone level / MGI
short tibia / MGI
decreased heart weight / MGI
increased liver weight / MGI
no phenotypic analysis / MGI
decreased circulating chloride level / MGI
thrombocytopenia / MGI
maternal effect / MGI
abnormal heart left ventricle morphology / MGI
abnormal T cell subpopulation ratio / MGI
decreased bone mass / MGI
decreased spleen weight / MGI
increased B cell number / MGI
decreased T cell number / MGI
decreased heart rate / MGI
decreased circulating serum albumin level / MGI
decreased body temperature / MGI
increased circulating creatinine level / MGI
increased blood urea nitrogen level / MGI
decreased pulmonary respiratory rate / MGI
decreased tidal volume / MGI
increased IgG1 level / MGI
increased IgG2b level / MGI
increased prepulse inhibition / MGI
decreased bone mineral content / MGI
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / MGI
decreased lung compliance / MGI
increased urination frequency / MGI
increased circulating lactate dehydrogenase level / MGI
increased mature NK cell number / MGI
abnormal IgG level / MGI

Information from provider