B6.129P2-Malt1^tm1Mak/Cnbc

Status	Available to order
EMMA ID	EM:06391
Citation information	RRID:IMSR_EM:06391 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.129P2-Malt1^tm1Mak/Cnbc
Alternative name	Malt1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Malt1^tm1Mak
Gene/Transgene symbol	Malt1

Information from provider

Provider	Tak W Mak
Provider affiliation	Mak Lab, Campbell Family Breast Cancer reseach Institute
Genetic information	Deletion of exon 8 with the neo targeting vector in antisense.
Phenotypic information	Malt1 is essential for T cell activation, proliferation, and IL-2 production in response to TCR ligation and strictly required for signal-specific NF-kappaB activation induced by the TCR, but not TNF-alpha or IL-1 signaling.
Breeding history	Backcrossed 10 times to C57BL/6.
References	Differential requirement for Malt1 in T and B cell antigen receptor signaling.;Ruland Jürgen, Duncan Gordon S, Wakeham Andrew, Mak Tak W, ;2003;Immunity;19;749-58; 14614861 The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.;Brüstle Anne, Brenner Dirk, Knobbe Christiane B, Lang Philipp A, Virtanen Carl, Hershenfield Brian M, Reardon Colin, Lacher Sonja M, Ruland Jürgen, Ohashi Pamela S, Mak Tak W, ;2012;The Journal of clinical investigation;122;4698-709; 23114599
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	yes

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous C57BL/6J males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Combined immunodeficiency due to MALT1 deficiency / Orphanet_397964

MGI phenotypes (gene matching)

abnormal immune system morphology / MGI
decreased IgG level / MGI
decreased IgM level / MGI
abnormal B cell differentiation / MGI
abnormal T cell differentiation / MGI
abnormal spleen marginal zone morphology / MGI
abnormal dendritic cell physiology / MGI
abnormal double-negative T cell morphology / MGI
decreased immunoglobulin level / MGI
abnormal T cell proliferation / MGI
decreased T cell proliferation / MGI
absent B-1a cells / MGI
decreased interleukin-2 secretion / MGI
impaired humoral immune response / MGI

Literature references

Differential requirement for Malt1 in T and B cell antigen receptor signaling.;Ruland Jürgen, Duncan Gordon S, Wakeham Andrew, Mak Tak W, ;2003;Immunity;19;749-58; 14614861
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.;Brüstle Anne, Brenner Dirk, Knobbe Christiane B, Lang Philipp A, Virtanen Carl, Hershenfield Brian M, Reardon Colin, Lacher Sonja M, Ruland Jürgen, Ohashi Pamela S, Mak Tak W, ;2012;The Journal of clinical investigation;122;4698-709; 23114599

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.129P2-Malt1tm1Mak/Cnbc