B6.129P2-Malt1tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06391 |
| International strain name | B6.129P2-Malt1tm1Mak/Cnbc |
| Alternative name | Malt1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Malt1tm1Mak, |
| Gene/Transgene symbol | Malt1 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Deletion of exon 8 with the neo targeting vector in antisense. |
| Phenotypic information | Malt1 is essential for T cell activation, proliferation, and IL-2 production in response to TCR ligation and strictly required for signal-specific NF-kappaB activation induced by the TCR, but not TNF-alpha or IL-1 signaling. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined immunodeficiency due to MALT1 deficiency / Orphanet_397964
Literature references
- Differential requirement for Malt1 in T and B cell antigen receptor signaling.;Ruland Jürgen, Duncan Gordon S, Wakeham Andrew, Mak Tak W, ;2003;Immunity;19;749-58; 14614861
- The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.;Brüstle Anne, Brenner Dirk, Knobbe Christiane B, Lang Philipp A, Virtanen Carl, Hershenfield Brian M, Reardon Colin, Lacher Sonja M, Ruland Jürgen, Ohashi Pamela S, Mak Tak W, ;2012;The Journal of clinical investigation;122;4698-709; 23114599