C57BL/6N-Cacna1btm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:06745
Citation informationRRID:IMSR_EM:06745 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Cacna1btm1a(KOMP)Wtsi/H
Alternative nameEPD0294_6_A07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCacna1btm1a(KOMP)Wtsi
Gene/Transgene symbolCacna1b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0294_6_A07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • hyperactivity / IMPC
  • abnormal gait / IMPC
  • abnormal locomotor behavior / IMPC
  • abnormal behavior / IMPC
  • decreased grip strength / IMPC
  • decreased thigmotaxis / IMPC
  • decreased fasting circulating glucose level / IMPC
  • decreased anxiety-related response / IMPC
  • increased exploration in new environment / IMPC
MGI phenotypes (gene matching)
  • hypertension / MGI
  • increased aggression towards mice / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • decreased startle reflex / MGI
  • abnormal sleep pattern / MGI
  • abnormal lipid level / MGI
  • abnormal hypothalamus secretion / MGI
  • increased thermal nociceptive threshold / MGI
  • decreased chemically-elicited antinociception / MGI
  • abnormal learning/memory/conditioning / MGI
  • abnormal sensory capabilities/reflexes/nociception / MGI
  • abnormal nervous system electrophysiology / MGI
  • alcohol aversion / MGI
  • increased heart rate / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating glucagon level / MGI
  • decreased circulating insulin level / MGI
  • abnormal discrimination learning / MGI
  • abnormal conditioned taste aversion behavior / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • impaired social transmission of food preference / MGI
  • abnormal frequency of paradoxical sleep / MGI
  • abnormal single cell response / MGI
  • abnormal summary potential / MGI
  • abnormal channel response / MGI
  • decreased alcohol consumption / MGI
  • nervous system phenotype / MGI
  • abnormal synaptic transmission / MGI
  • abnormal sympathetic nervous system physiology / MGI
  • abnormal baroreceptor physiology / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • improved glucose tolerance / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • behavior/neurological phenotype / MGI
  • hyporesponsive to tactile stimuli / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased circulating leptin level / MGI
  • abnormal long term spatial reference memory / MGI
  • increased chemical nociceptive threshold / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • fragmentation of sleep/wake states / MGI
  • impaired conditioned place preference behavior / MGI
  • abnormal behavioral response to xenobiotic / MGI
  • enhanced behavioral response to alcohol / MGI
  • impaired behavioral response to alcohol / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI

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