B6.129P2-Brca2tm2Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:06747 |
| International strain name | B6.129P2-Brca2tm2Mak/Cnbc |
| Alternative name | BrCa2 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Brca2tm2Mak, |
| Gene/Transgene symbol | Brca2 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Mak Lab, Campbell Family Breast Cancer reseach Institute |
| Genetic information | Conditional targeted mutation of exons 9 and 10 flanked by loxP sites. |
| Phenotypic information | Brca2-null mice have a defect in embryonic cellular proliferation and die in utero. tBrca2/ T cells were more likely than wild-type cells to undergo spontaneous apoptosis, but apoptosed normally in response to restimulation or DNA-damaging stress signals. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary breast and ovarian cancer syndrome / Orphanet_145
- Fanconi anemia / Orphanet_84
- Inherited cancer-predisposing syndrome due to biallelic BRCA2 mutations / Orphanet_319462
- Cholangiocarcinoma / Orphanet_70567
Literature references
- Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.;Cheung Alison M Y, Hande M Prakash, Jalali Farid, Tsao Ming-Sound, Skinnider Brian, Hirao Atsushi, McPherson J Peter, Karaskova Jana, Suzuki Akira, Wakeham Andrew, You-Ten Annick, Elia Andrew, Squire Jeremy, Bristow Rob, Hakem Razqallah, Mak Tak W, ;2002;Cancer research;62;6194-204; 12414647
- Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.;Cheung Alison M Y, Elia Andrew, Tsao Ming-Sound, Done Susan, Wagner Kay-Uwe, Hennighausen Lothar, Hakem Razqallah, Mak Tak W, ;2004;Cancer research;64;1959-65; 15026330