C3.C-Pde6b+/Ieg
| Status | Available to order |
| EMMA ID | EM:06821 |
| International strain name | C3.C-Pde6b+/Ieg |
| Alternative name | C3H sighted |
| Strain type | Other |
| Allele/Transgene symbol | Pde6b+, |
| Gene/Transgene symbol | Pde6b |
Information from provider
| Provider | Oliver Puk |
| Provider affiliation | Institut fuer Entwicklungsgenetik, AG Graw, Helmholtz Zentrum Muenchen |
| Genetic information | Pde6b rd1 is removed by an intact Pde6b allele. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt. |
| Phenotypic information | C3H sighted strain carries a functional Pde6b allele that avoids retinal degeneration. |
| Breeding history | Incross, 10 generations |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Retinitis pigmentosa / Orphanet_791
- Congenital stationary night blindness / Orphanet_215
Literature references
- "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?;Hoelter Sabine M, Dalke Claudia, Kallnik Magdalena, Becker Lore, Horsch Marion, Schrewe Anja, Favor Jack, Klopstock Thomas, Beckers Johannes, Ivandic Boris, Gailus-Durner Valérie, Fuchs Helmut, Hrabé de Angelis Martin, Graw Jochen, Wurst Wolfgang, ;2008;Frontiers in bioscience : a journal and virtual library;13;5810-23; 18508624