C57BL/6N-Atm1Brd 4933434E20Riktm1a(EUCOMM)Wtsi/WtsiCnrm

Status

Available to order

EMMA IDEM:06846
International strain nameC57BL/6N-Atm1Brd 4933434E20Riktm1a(EUCOMM)Wtsi/WtsiCnrm
Alternative nameEPD0371_1_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbol4933434E20Riktm1a(EUCOMM)Wtsi,
Gene/Transgene symbol4933434E20Rik
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0371_1_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating fructosamine level / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (allele matching)
  • abnormal vertebral body morphology / MGI
  • overriding aortic valve / MGI
  • abnormal interatrial septum morphology / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • enlarged liver sinusoidal spaces / MGI
  • abnormal pineal gland morphology / MGI
  • abnormal forebrain morphology / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hindbrain morphology / MGI
  • fused dorsal root ganglion / MGI
  • small superior cervical ganglion / MGI
  • abnormal lens morphology / MGI
  • abnormal larynx morphology / MGI
  • abnormal heart atrium morphology / MGI
  • anal atresia / MGI
  • intestinal/bowel diverticulum / MGI
  • urinary bladder hypoplasia / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • abnormal heart right atrium morphology / MGI
  • right aortic arch / MGI
  • retroesophageal right subclavian artery / MGI
  • abnormal vertebral arch morphology / MGI
  • absent vertebral arch / MGI
  • fusion of vertebral arches / MGI
  • abnormal heart position or orientation / MGI
  • arteriovenous malformation / MGI
  • dorsal root ganglion hypoplasia / MGI
  • abnormal brain internal capsule morphology / MGI
  • enlarged lymphatic vessel / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • abnormal pectinate muscle morphology / MGI
  • abnormal aortic valve cusp morphology / MGI
  • abnormal pulmonary valve cusp morphology / MGI
  • herniated liver / MGI
  • double ureter / MGI
  • absent hypoglossal canal / MGI
  • thin hypoglossal nerve / MGI
  • absent hypoglossal nerve / MGI
  • abnormal hypoglossal nerve topology / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • abnormal vitelline vein connection / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal ductus venosus valve topology / MGI
  • absent costovertebral joint / MGI
  • abnormal dural venous sinus morphology / MGI
  • absent lobe of thyroid gland / MGI
  • retro-esophageal left subclavian artery / MGI
  • abnormal infrahyoid muscle connection / MGI
  • reduced sympathetic cervical ganglion size / MGI
  • blood in lymph vessels / MGI
  • abnormal vertebral artery topology / MGI
  • abnormal Wolffian duct connection / MGI
  • embryo cyst / MGI
  • heterochrony / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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