MGI phenotypes (allele matching)
B6.129-Fn1tm2Feb/Cnrm
| Status | Available to order |
| EMMA ID | EM:00069 |
| International strain name | B6.129-Fn1tm2Feb/Cnrm |
| Alternative name | Fn1-del. |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Fn1tm2Feb, |
| Gene/Transgene symbol | Fn1 |
Information from provider
| Provider | Francisco E. Baralle |
| Provider affiliation | ICGEB-Inter.Centre Genetic Engineering Biotechnology |
| Genetic information | Modification of the natural alternative splicing pattern of the Fn1 extra domain A (EDA) exon by deletion of the EDA exon sequence. |
| Phenotypic information | Phenotype defects under analysis. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Fibronectin glomerulopathy / Orphanet_84090
- Spondylometaphyseal dysplasia, 'corner fracture' type / Orphanet_93315
Literature references
- Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan.;Muro Andres F, Chauhan Anil K, Gajovic Srecko, Iaconcig Alessandra, Porro Fabiola, Stanta Giorgio, Baralle Francisco E, ;2003;The Journal of cell biology;162;149-60; 12847088