C57BL/6-Rack1tm1Sbif/Cnrm

Status

Available to order

EMMA IDEM:07110
International strain nameC57BL/6-Rack1tm1Sbif/Cnrm
Alternative nameDF/RACK1
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolRack1tm1Sbif,
Gene/Transgene symbolRack1

Information from provider

ProviderSTEFANO BIFFO
Provider affiliationSan Raffaele Scientific Institute
Genetic informationHypomorphic expression of the Rack1 locus (RACK1 protein) due to interference by the neomycin cassette.
Phenotypic informationLethal at gastrulation in homozygosis. Bellyspot phenotype in heterozygosis with reduction of translational efficiency.
References
  • RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.;Volta Viviana, Beugnet Anne, Gallo Simone, Magri Laura, Brina Daniela, Pesce Elisa, Calamita Piera, Sanvito Francesca, Biffo Stefano, ;2013;Cellular and molecular life sciences : CMLS;70;1439-50; 23212600
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • belly spot / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • postnatal growth retardation / MGI
  • non-pigmented tail tip / MGI
  • decreased tail pigmentation / MGI
  • decreased foot pigmentation / MGI
  • abnormal translation / MGI
  • abnormal embryo development / MGI
  • absent egg cylinders / MGI
  • embryonic lethality between implantation and placentation, complete penetrance / MGI

Literature references

  • RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.;Volta Viviana, Beugnet Anne, Gallo Simone, Magri Laura, Brina Daniela, Pesce Elisa, Calamita Piera, Sanvito Francesca, Biffo Stefano, ;2013;Cellular and molecular life sciences : CMLS;70;1439-50; 23212600

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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