129S2.Cg-Ago2tm1.1Doca/Cnrm
| Status | Available to order |
| EMMA ID | EM:07112 |
| International strain name | 129S2.Cg-Ago2tm1.1Doca/Cnrm |
| Alternative name | 129S2/SvHsd - Ago2S388A |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Ago2tm1.1Doca, |
| Gene/Transgene symbol | Ago2 |
Information from provider
| Provider | Donal O'Carroll |
| Provider affiliation | Mouse Biology Unit, European Molecular Biology Laboratory |
| Genetic information | Two point mutations in exon 10, converting Serine 388 in an Alanine residue. Residual LoxP site between exon 8 and 9 due to removal of neomycin resistance cassette. |
| Phenotypic information | Homozygous mice for the point mutation are born with subMendelian frequencies in this genetic background. |
| Breeding history | The mice were backcrossed 9 times with 129S2/SvHsd mice from Harlan. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084