IMPC phenotypes (gene matching)
B6.129P2-Trim3tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07229 |
| Citation information | RRID:IMSR_EM:07229 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Trim3tm1Mak/Cnbc |
| Alternative name | Berp (Trim3 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Trim3tm1Mak |
| Gene/Transgene symbol | Trim3 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | The targeting construct replaced Exons 1 and 2 with a neomycin cassette in the reverse direction of transcription. |
| Phenotypic information | BERP-deficient mice exhibit increased resistance to pentylenetetrazol-induced seizures. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Literature references
- Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.;Cheung Carol C, Yang Caimei, Berger Thorsten, Zaugg Kathrin, Reilly Patrick, Elia Andrew J, Wakeham Andrew, You-Ten Annick, Chang Ning, Li Lijun, Wan Qi, Mak Tak Wah, ;2010;Proceedings of the National Academy of Sciences of the United States of America;107;11883-8; 20543135