IMPC phenotypes (gene matching)
B6.129P2-Faddtm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07233 |
| Citation information | RRID:IMSR_EM:07233 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Faddtm1Mak/Cnbc |
| Alternative name | FADD/FLIP (Fadd |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Faddtm1Mak |
| Gene/Transgene symbol | Fadd |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | The targeting construct replaces the entire coding region (2 exons) with PGK Neo gene in the reverse orientation. |
| Phenotypic information | Mice with a deletion in the FADD gene did not survive beyond day 11.5 of embryogenesis; these mice showed signs of cardiac failure and abdominal hemorrhage. |
| Breeding history | Pure C57BL/6, backcrossed 10 times. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- FADD-related immunodeficiency / Orphanet_306550
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- trabecula carnea hypoplasia / MGI
- internal hemorrhage / MGI
- decreased embryo size / MGI
- thin myocardium / MGI
- embryonic growth retardation / MGI
- abnormal myocardium layer morphology / MGI
- embryonic lethality / MGI
- decreased sensitivity to induced cell death / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- decreased fibroblast apoptosis / MGI
Literature references
- Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
- FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.;Yeh W C, de la Pompa J L, McCurrach M E, Shu H B, Elia A J, Shahinian A, Ng M, Wakeham A, Khoo W, Mitchell K, El-Deiry W S, Lowe S W, Goeddel D V, Mak T W, ;1998;Science (New York, N.Y.);279;1954-8; 9506948