B6.129P2-Bag6tm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07234 |
| International strain name | B6.129P2-Bag6tm1Mak/Cnbc |
| Alternative name | Bat 3 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bag6tm1Mak, |
| Gene/Transgene symbol | Bag6 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | Targeting construct deletes exons 2-6 with neomycin cassette. |
| Phenotypic information | Thymocytes from Bag6 (Bat3) deficient mice exhibit reduced induction of Bbc3 (Puma) and Cdkn1 (p21/CDKI/WAF1), and are resistant to DNA damage-induced apoptosis in vivo. Our data indicate that Bat3 is a novel and essential regulator of Trp53 (p53)-mediated responses to genotoxic stress, and that Bat3 controls DNA damage-induced acetylation of p53. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Literature references
- Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.;Sasaki Toru, Gan Eugene C, Wakeham Andrew, Kornbluth Sally, Mak Tak W, Okada Hitoshi, ;2007;Genes & development;21;848-61; 17403783