B6.129P2-Bag6tm1Mak/Cnbc

Status

Available to order

EMMA IDEM:07234
Citation informationRRID:IMSR_EM:07234 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Bag6tm1Mak/Cnbc
Alternative nameBat 3
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolBag6tm1Mak
Gene/Transgene symbolBag6

Information from provider

ProviderTak W Mak
Provider affiliationDivision of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute
Genetic informationTargeting construct deletes exons 2-6 with neomycin cassette.
Phenotypic informationThymocytes from Bag6 (Bat3) deficient mice exhibit reduced induction of Bbc3 (Puma) and Cdkn1 (p21/CDKI/WAF1), and are resistant to DNA damage-induced apoptosis in vivo. Our data indicate that Bat3 is a novel and essential regulator of Trp53 (p53)-mediated responses to genotoxic stress, and that Bat3 controls DNA damage-induced acetylation of p53.
Breeding historyBackcrossed 10 times to C57BL/6.
References
  • Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.;Sasaki Toru, Gan Eugene C, Wakeham Andrew, Kornbluth Sally, Mak Tak W, Okada Hitoshi, ;2007;Genes & development;21;848-61; 17403783
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J males

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal kidney development / MGI
  • abnormal telencephalon morphology / MGI
  • abnormal midbrain morphology / MGI
  • abnormal brain development / MGI
  • exencephaly / MGI
  • pulmonary hypoplasia / MGI
  • edema / MGI
  • respiratory failure / MGI
  • abnormal kidney morphology / MGI
  • dilated renal tubules / MGI
  • renal hypoplasia / MGI
  • single kidney / MGI
  • decreased renal glomerulus number / MGI
  • impaired branching involved in ureteric bud morphogenesis / MGI
  • impaired lung alveolus development / MGI
  • abnormal ureteric bud morphology / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • small ureteric bud / MGI
  • abnormal ureteric bud elongation / MGI
  • impaired branching involved in terminal bronchiole morphogenesis / MGI
  • neonatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • renal glomerulus hypertrophy / MGI
  • increased kidney apoptosis / MGI
  • increased kidney cell proliferation / MGI

Literature references

  • Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.;Sasaki Toru, Gan Eugene C, Wakeham Andrew, Kornbluth Sally, Mak Tak W, Okada Hitoshi, ;2007;Genes & development;21;848-61; 17403783

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).