MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
B6.129P2-Diablotm1Mak/Cnbc
| Status | Available to order |
| EMMA ID | EM:07235 |
| Citation information | RRID:IMSR_EM:07235 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Diablotm1Mak/Cnbc |
| Alternative name | SMAC (Diablo |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Diablotm1Mak |
| Gene/Transgene symbol | Diablo |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | Exons 2 to 4 were replaced with PGK-neo and diphtheria toxin A (DT-A) was added for negative selection. |
| Phenotypic information | Diablo (Smac) -/- mice were viable, grew, and matured normally and did not show any histological abnormalities. Although the cleavage in vitro of procaspase-3 was inhibited in lysates of Smac -/- cells, all types of cultured Smac -/- cells tested responded normally to all apoptotic stimuli applied. There were also no detectable differences in Fas-mediated apoptosis in the liver in vivo. Our data strongly suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac function. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
Literature references
- Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.;Yeh W C, Itie A, Elia A J, Ng M, Shu H B, Wakeham A, Mirtsos C, Suzuki N, Bonnard M, Goeddel D V, Mak T W, ;2000;Immunity;12;633-42; 10894163
- Generation and characterization of Smac/DIABLO-deficient mice.;Okada Hitoshi, Suh Woong-Kyung, Jin Jianping, Woo Minna, Du Chunying, Elia Andrew, Duncan Gordon S, Wakeham Andrew, Itie Annick, Lowe Scott W, Wang Xiaodong, Mak Tak W, ;2002;Molecular and cellular biology;22;3509-17; 11971981