B6.Cg-Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:07264 |
| International strain name | B6.Cg-Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep/Cnrm |
| Alternative name | Rosa26::Cl-Sensor |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1(CAG-ECFP/EYFP*)Phep, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | Adriano Buzzati-Traverso Campus, EMBL Monterotondo |
| Genetic information | This is a reporter allele for cre recombinase activity that expresses a chloride sensitive protein following cre-mediated inversion of the intervening sequences and irreversible excision of the neomycin stop cassette. |
| Phenotypic information | The cre recombinase-dependent conditional expression of chloride sensitive protein allows ratiometric monitoring of intracellular chloride in specific cell types in vivo. |
| Breeding history | A9, C57BL/6 x 129P2/OlaHsd)F1, targeted ES cells. Mutant mice were backcrossed to C57BL/6 for 6 generations. They are currently inbreeding. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Transgenic mouse lines for non-invasive ratiometric monitoring of intracellular chloride.;Batti Laura, Mukhtarov Marat, Audero Enrica, Ivanov Anton, Paolicelli Rosa Chiara, Zurborg Sandra, Gross Cornelius, Bregestovski Piotr, Heppenstall Paul A, ;2013;Frontiers in molecular neuroscience;6;11; 23734096