B6Brd;B6N-Tyrc-Brd Atm1Brd Kif3btm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07379
Citation informationRRID:IMSR_EM:07379 

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International strain nameB6Brd;B6N-Tyrc-Brd Atm1Brd Kif3btm1a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0619_3_A05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKif3btm1a(EUCOMM)Wtsi
Gene/Transgene symbolKif3b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0619_3_A05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • prenatal lethality prior to heart atrial septation / IMPC
  • increased bone mineral content / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased grip strength / IMPC
MGI phenotypes (gene matching)
  • distended pericardium / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal spinal cord morphology / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • abnormal left-right axis patterning / MGI
  • absent embryonic cilia / MGI
  • abnormal direction of heart looping / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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