129S5;B6N-Kdm6atm2a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:07380
Citation informationRRID:IMSR_EM:07380 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain name129S5;B6N-Kdm6atm2a(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0506_3_A01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolKdm6atm2a(EUCOMM)Wtsi
Gene/Transgene symbolKdm6a
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0506_3_A01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • abnormal heart development / MGI
  • thin ventricular wall / MGI
  • cranioschisis / MGI
  • open neural tube / MGI
  • anemia / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • pale yolk sac / MGI
  • pericardial edema / MGI
  • abnormal developmental patterning / MGI
  • no abnormal phenotype detected / MGI
  • small heart / MGI
  • abnormal notochord morphology / MGI
  • abnormal cardiovascular development / MGI
  • no phenotypic analysis / MGI
  • abnormal neural tube closure / MGI
  • delayed somite formation / MGI
  • embryonic growth retardation / MGI
  • caudal body truncation / MGI
  • failure of initiation of embryo turning / MGI
  • failure of heart looping / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • muscle phenotype / MGI
  • increased trophoblast giant cell number / MGI
  • myocardial trabeculae hypoplasia / MGI
  • thin interventricular septum / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • abnormal muscle precursor cell morphology / MGI
  • impaired skeletal muscle regeneration / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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