IMPC phenotypes (gene matching)
C57BL/6N-Fgf8tm1a(KOMP)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:07495 |
| Citation information | RRID:IMSR_EM:07495 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Fgf8tm1a(KOMP)Wtsi/H |
| Alternative name | EPD0383_6_A10 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Fgf8tm1a(KOMP)Wtsi |
| Gene/Transgene symbol | Fgf8 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from KOMP ES clone EPD0383_6_A10. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Normosmic congenital hypogonadotropic hypogonadism / Orphanet_432
- Kallmann syndrome / Orphanet_478
- Alobar holoprosencephaly / Orphanet_93925
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
- Holoprosencephaly / Orphanet_2162
MGI phenotypes (gene matching)
- abnormal heart development / MGI
- abnormal heart tube morphology / MGI
- abnormal craniofacial morphology / MGI
- syndactyly / MGI
- abnormal pituitary gland morphology / MGI
- abnormal hypothalamus morphology / MGI
- absent cerebellum / MGI
- abnormal midbrain morphology / MGI
- open neural tube / MGI
- small embryonic telencephalon / MGI
- decreased body weight / MGI
- cyanosis / MGI
- abnormal ectoderm development / MGI
- abnormal mesoderm development / MGI
- absent mesoderm / MGI
- abnormal somite development / MGI
- decreased embryo size / MGI
- abnormal allantois morphology / MGI
- edema / MGI
- prenatal lethality / MGI
- postnatal lethality / MGI
- abnormal developmental patterning / MGI
- abnormal cardiovascular system morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal primitive streak morphology / MGI
- abnormal chorion morphology / MGI
- abnormal pharyngeal arch morphology / MGI
- decreased neuron apoptosis / MGI
- absent olfactory bulb / MGI
- nervous system phenotype / MGI
- abnormal embryonic epiblast morphology / MGI
- abnormal craniofacial development / MGI
- fetal growth retardation / MGI
- abnormal neural fold formation / MGI
- abnormal amnion morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- absent somites / MGI
- absent inferior colliculus / MGI
- absent primitive node / MGI
- abnormal neural crest cell apoptosis / MGI
- abnormal truncus arteriosus septation / MGI
- mortality/aging / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- absent heart / MGI
- abnormal cardiogenic mesoderm morphology / MGI
- abnormal primitive streak elongation / MGI
- third pharyngeal arch artery hypoplasia / MGI