STOCK Ankrd11tm1a(EUCOMM)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:07651
Citation informationRRID:IMSR_EM:07651 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Ankrd11tm1a(EUCOMM)Wtsi/IcsOrl
Alternative nameEPD0678_1_F03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAnkrd11tm1a(EUCOMM)Wtsi
Gene/Transgene symbolAnkrd11
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0678_1_F03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased bone mineral density / IMPC
  • decreased startle reflex / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased lean body mass / IMPC
  • increased circulating cholesterol level / IMPC
  • increased total body fat amount / IMPC
  • abnormal vitreous body morphology / IMPC
  • abnormal response to new environment / IMPC
  • decreased heart weight / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal head morphology / IMPC
  • abnormal startle reflex / IMPC
  • increased bone mineral content / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased body length / IMPC
  • abnormal embryo development / IMPC
  • increased circulating HDL cholesterol level / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal nasal bone morphology / MGI
  • kyphosis / MGI
  • domed cranium / MGI
  • increased cranium width / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased embryo size / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal bone structure / MGI
  • abnormal metopic suture morphology / MGI
  • decreased bone mass / MGI
  • failure of initiation of embryo turning / MGI
  • short frontal bone / MGI
  • enlarged parietal bone / MGI
  • short nasal bone / MGI
  • decreased osteoclast cell number / MGI
  • decreased circulating leptin level / MGI
  • abnormal frontonasal suture morphology / MGI
  • decreased compact bone area / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • short face / MGI
  • broad face / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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