IMPC phenotypes (gene matching)
C57BL/6NTac-Raf1tm1a(EUCOMM)Wtsi/IcsOrl
| Status | Available to order |
| EMMA ID | EM:07652 |
| Citation information | RRID:IMSR_EM:07652 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Raf1tm1a(EUCOMM)Wtsi/IcsOrl |
| Alternative name | EPD0065_4_B07 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Raf1tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Raf1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0065_4_B07. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6NTac males, wild-type C57BL/6NTac females |
| Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Noonan syndrome / Orphanet_648
- Noonan syndrome with multiple lentigines / Orphanet_500
- Familial isolated dilated cardiomyopathy / Orphanet_154
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- increased monocyte cell number / MGI
- enlarged heart / MGI
- distended pericardium / MGI
- decreased cell proliferation / MGI
- small hair follicles / MGI
- underdeveloped hair follicles / MGI
- ruffled hair / MGI
- increased cranium width / MGI
- flattened snout / MGI
- liver hypoplasia / MGI
- small liver / MGI
- pale liver / MGI
- abnormal hepatocyte morphology / MGI
- enlarged spleen / MGI
- tremors / MGI
- abnormal epidermal layer morphology / MGI
- thin epidermis / MGI
- abnormal epidermis stratum corneum morphology / MGI
- abnormal dermal layer morphology / MGI
- thin dermal layer / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ocular hypertelorism / MGI
- eyelids open at birth / MGI
- abnormal retina morphology / MGI
- hunched posture / MGI
- abnormal cardiovascular system physiology / MGI
- anemia / MGI
- abnormal vasculogenesis / MGI
- cardiac hypertrophy / MGI
- abnormal apoptosis / MGI
- abnormal somite development / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- abnormal placenta labyrinth morphology / MGI
- absent vitelline blood vessels / MGI
- embryonic growth arrest / MGI
- hemorrhage / MGI
- respiratory failure / MGI
- prenatal lethality / MGI
- premature death / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal pulmonary alveolus morphology / MGI
- dilated cardiomyopathy / MGI
- increased heart weight / MGI
- thick ventricular wall / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- increased cardiac output / MGI
- small lung / MGI
- pallor / MGI
- abnormal facial morphology / MGI
- increased left ventricle systolic pressure / MGI
- abnormal heart left ventricle morphology / MGI
- embryonic growth retardation / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- small placenta / MGI
- increased response of heart to induced stress / MGI
- enlarged myocardial fiber / MGI
- decreased placenta weight / MGI
- decreased cardiac muscle contractility / MGI
- cardiovascular system phenotype / MGI
- hematopoietic system phenotype / MGI
- increased cardiac muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- increased apoptosis / MGI
- embryonic lethality during organogenesis / MGI
- abnormal common myeloid progenitor cell morphology / MGI
- decreased cranium height / MGI
- decreased cranium width / MGI
- enlarged heart right atrium / MGI
- increased heart ventricle size / MGI
- abnormal placental labyrinth vasculature morphology / MGI
- increased sensitivity to induced cell death / MGI
- decreased sensitivity to induced cell death / MGI
- abnormal liver sinusoid morphology / MGI
- decreased embryo weight / MGI
- decreased fetal weight / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal cranium size / MGI
- increased heart left ventricle size / MGI
- thick interventricular septum / MGI
- abnormal heart left ventricle pressure / MGI
- neonatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
- increased cardiac stroke volume / MGI
- decreased spongiotrophoblast size / MGI
- increased hepatoblast apoptosis / MGI
- increased fibroblast apoptosis / MGI
- increased embryonic tissue cell apoptosis / MGI