C57BL/6NTac-Cacnb4tm1a(EUCOMM)Hmgu/IcsOrl

Status

Available to order

EMMA IDEM:07656
Citation informationRRID:IMSR_EM:07656 

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International strain nameC57BL/6NTac-Cacnb4tm1a(EUCOMM)Hmgu/IcsOrl
Alternative nameHEPD0507_8_G08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCacnb4tm1a(EUCOMM)Hmgu
Gene/Transgene symbolCacnb4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0507_8_G08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased startle reflex / IMPC
IMPC phenotypes (gene matching)
  • increased startle reflex / IMPC
MGI phenotypes (gene matching)
  • abnormal head movements / MGI
  • pituitary gland hyperplasia / MGI
  • small spleen / MGI
  • enlarged lymph nodes / MGI
  • small thymus / MGI
  • abnormal motor neuron morphology / MGI
  • convulsive seizures / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • absent corpus luteum / MGI
  • decreased body size / MGI
  • abnormal locomotor behavior / MGI
  • ataxia / MGI
  • circling / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • abnormal posture / MGI
  • impaired righting response / MGI
  • impaired limb coordination / MGI
  • postnatal growth retardation / MGI
  • abnormal thymus involution / MGI
  • reduced fertility / MGI
  • male infertility / MGI
  • seizures / MGI
  • abnormal fear/anxiety-related behavior / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal lymph node morphology / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • tonic seizures / MGI
  • abnormal locomotor activation / MGI
  • nervous system phenotype / MGI
  • clonic seizures / MGI
  • increased length of allograft survival / MGI
  • abnormal behavior / MGI
  • abnormal brain wave pattern / MGI
  • decreased lymphocyte cell number / MGI
  • diarrhea / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • lethargy / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal nerve conduction / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal eye electrophysiology / MGI
  • decreased Peyer's patch number / MGI
  • small Peyer's patches / MGI
  • increased IgG1 level / MGI
  • decreased interferon-gamma secretion / MGI
  • abnormal interleukin secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased nerve conduction velocity / MGI
  • impaired behavioral response to xenobiotic / MGI
  • absent thymus corticomedullary boundary / MGI
  • facial muscle spasm / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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