C57BL/6N-Chrna7tm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:07778
Citation informationRRID:IMSR_EM:07778 

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International strain nameC57BL/6N-Chrna7tm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0577_3_E08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolChrna7tm1a(EUCOMM)Hmgu
Gene/Transgene symbolChrna7
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0577_3_E08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating cholesterol level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • abnormal bone structure / IMPC
MGI phenotypes (gene matching)
  • decreased neutrophil cell number / MGI
  • tremors / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal somatosensory cortex morphology / MGI
  • abnormal seizure response to pharmacological agent / MGI
  • failure of neuromuscular synapse presynaptic differentiation / MGI
  • decreased anxiety-related response / MGI
  • hypoactivity / MGI
  • abnormal suckling behavior / MGI
  • abnormal spatial learning / MGI
  • decreased IgG level / MGI
  • reduced fertility / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal myeloblast morphology/development / MGI
  • decreased immunoglobulin level / MGI
  • asthenozoospermia / MGI
  • no phenotypic analysis / MGI
  • increased neuron apoptosis / MGI
  • abnormal GABAergic neuron morphology / MGI
  • nervous system phenotype / MGI
  • abnormal GABA-mediated receptor currents / MGI
  • abnormal brain interneuron morphology / MGI
  • decreased CNS synapse formation / MGI
  • increased lymphocyte cell number / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal spatial working memory / MGI
  • impaired olfaction / MGI
  • abnormal interleukin level / MGI
  • abnormal tumor necrosis factor level / MGI
  • prolonged estrous cycle / MGI
  • abnormal nicotine-mediated receptor currents / MGI
  • abnormal cerebral cortex pyramidal cell morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal airway basal cell differentiation / MGI
  • airway basal cell hyperplasia / MGI
  • decreased erythroblast number / MGI
  • abnormal GABAergic neuron physiology / MGI

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Genotyping protocol

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