C57BL/6N-Slc9a4tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:07780
Citation informationRRID:IMSR_EM:07780 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Slc9a4tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0644_4_C05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSlc9a4tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSlc9a4
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0644_4_C05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased bone mineral content / IMPC
  • decreased prepulse inhibition / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased bone mineral density / IMPC
  • decreased startle reflex / IMPC
MGI phenotypes (gene matching)
  • abnormal stomach glandular epithelium morphology / MGI
  • gastric necrosis / MGI
  • stomach inflammation / MGI
  • abnormal mucous neck cell morphology / MGI
  • abnormal gastric parietal cell morphology / MGI
  • abnormal gastric chief cell morphology / MGI
  • growth/size/body region phenotype / MGI
  • hypochlorhydria / MGI
  • abnormal stomach mucosa morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).