C57BL/6NTac-Fgf9tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:07970
Citation informationRRID:IMSR_EM:07970 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Fgf9tm1a(KOMP)Wtsi/H
Alternative nameEPD0195_3_H07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFgf9tm1a(KOMP)Wtsi
Gene/Transgene symbolFgf9
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0195_3_H07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • enlarged heart / IMPC
  • abnormal body wall morphology / IMPC
  • hyperactivity / IMPC
  • increased heart weight / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal retina vasculature morphology / IMPC
  • increased startle reflex / IMPC
  • cleft palate / IMPC
  • abnormal embryo size / IMPC
  • cataract / IMPC
MGI phenotypes (gene matching)
  • abnormal tympanic ring morphology / MGI
  • abnormal cochlea morphology / MGI
  • delayed bone ossification / MGI
  • short premaxilla / MGI
  • cleft palate / MGI
  • abnormal tooth development / MGI
  • abnormal sternum morphology / MGI
  • abnormal cartilage development / MGI
  • abnormal heart development / MGI
  • abnormal cecum morphology / MGI
  • abnormal small intestine morphology / MGI
  • short limbs / MGI
  • abnormal radius morphology / MGI
  • synostosis / MGI
  • kinked tail / MGI
  • short tail / MGI
  • abnormal testis morphology / MGI
  • abnormal lung morphology / MGI
  • pulmonary hypoplasia / MGI
  • ocular hypertelorism / MGI
  • cataract / MGI
  • small lens / MGI
  • abnormal suckling behavior / MGI
  • cyanosis / MGI
  • abnormal digestive system physiology / MGI
  • postnatal growth retardation / MGI
  • testis hypoplasia / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • hypopnea / MGI
  • postnatal lethality / MGI
  • abnormal vision / MGI
  • no abnormal phenotype detected / MGI
  • abnormal primary sex determination / MGI
  • heart hypoplasia / MGI
  • exophthalmos / MGI
  • dilated heart left ventricle / MGI
  • dilated heart right ventricle / MGI
  • short tibia / MGI
  • short fibula / MGI
  • abnormal joint morphology / MGI
  • primary sex reversal / MGI
  • ovotestis / MGI
  • curly tail / MGI
  • short femur / MGI
  • dilated heart atrium / MGI
  • fused joints / MGI
  • calcified joint / MGI
  • abnormal voluntary movement / MGI
  • abnormal fetal cardiomyocyte proliferation / MGI
  • small lung / MGI
  • pallor / MGI
  • abnormal long bone morphology / MGI
  • abnormal Sertoli cell development / MGI
  • abnormal intervertebral disk morphology / MGI
  • short sternum / MGI
  • short humerus / MGI
  • short radius / MGI
  • short ulna / MGI
  • short nasal bone / MGI
  • abnormal vertebral arch morphology / MGI
  • vertebral fusion / MGI
  • fusion of vertebral arches / MGI
  • caudal vertebral fusion / MGI
  • wide ribs / MGI
  • abnormal small intestine crypts of Lieberkuhn morphology / MGI
  • epididymis hypoplasia / MGI
  • hypoxia / MGI
  • abnormal temporal bone morphology / MGI
  • abnormal humerus morphology / MGI
  • abnormal incisor morphology / MGI
  • renal/urinary system phenotype / MGI
  • endocrine/exocrine gland phenotype / MGI
  • respiratory system phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal lens development / MGI
  • decreased lung weight / MGI
  • abnormal limb development / MGI
  • abnormal testis cord formation / MGI
  • disorganized testis cords / MGI
  • decreased number of peritubular myoid cells / MGI
  • dilated heart ventricle / MGI
  • increased diameter of femur / MGI
  • increased diameter of fibula / MGI
  • increased diameter of humerus / MGI
  • increased diameter of radius / MGI
  • increased diameter of tibia / MGI
  • increased diameter of ulna / MGI
  • enlarged heart atrium / MGI
  • decreased fetal weight / MGI
  • enlarged eye anterior chamber / MGI
  • cleft secondary palate / MGI
  • abnormal coccyx morphology / MGI
  • mortality/aging / MGI
  • abnormal branching involved in lung morphogenesis / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • abnormal lung-associated mesenchyme development / MGI
  • abnormal mesenchymal cell proliferation involved in lung development / MGI
  • increased chondrocyte number / MGI
  • midface hypoplasia / MGI
  • abnormal Leydig cell differentiation / MGI
  • increased bone ossification / MGI
  • high forehead / MGI
  • premature coronal suture closure / MGI
  • premature sagittal suture closure / MGI
  • enlarged Meckel's cartilage / MGI
  • misaligned incisors / MGI
  • abnormal knee joint morphology / MGI

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