- abnormal vertebrae morphology / IMPC
- enlarged heart / IMPC
- increased circulating phosphate level / IMPC
- abnormal embryo size / IMPC
- increased heart weight / IMPC
- abnormal retinal inner nuclear layer morphology / IMPC
- increased lean body mass / IMPC
- improved glucose tolerance / IMPC
- increased circulating creatinine level / IMPC
- increased CD8-positive, alpha-beta T cell number / IMPC
- decreased mean platelet volume / IMPC
- decreased total body fat amount / IMPC
- preweaning lethality, complete penetrance / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- abnormal sleep behavior / IMPC
- increased food intake / IMPC
- increased fluid intake / IMPC
- decreased total retina thickness / IMPC
C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ieg
Status | Available to order |
EMMA ID | EM:08114 |
International strain name | C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ieg |
Alternative name | EPD0211_3_A05 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Dbn1tm1b(KOMP)Wtsi, |
Gene/Transgene symbol | Dbn1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Genetic information | This mouse line originates from KOMP ES clone EPD0211_3_A05. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6NTacUSA, wild-type C57BL/6NTacUSA |
Stage of embryos | 2-cell |
Disease and phenotype information
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- enlarged liver sinusoidal spaces / MGI
- abnormal forebrain morphology / MGI
- abnormal telencephalon morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal brain internal capsule morphology / MGI
- abnormal cervical rib / MGI
- abnormal hypoglossal canal morphology / MGI
- absent hypoglossal canal / MGI
- thin hypoglossal nerve / MGI
- absent hypoglossal nerve / MGI
- abnormal brachial plexus formation / MGI
- abnormal Wolffian duct connection / MGI
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