B6NCrl;B6N-Atm1Brd Lcp2tm1a(KOMP)Wtsi/CipheOrl

Status

Available to order

EMMA IDEM:08197
Citation informationRRID:IMSR_EM:08197 

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International strain nameB6NCrl;B6N-Atm1Brd Lcp2tm1a(KOMP)Wtsi/CipheOrl
Alternative nameEPD0396_3_B12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLcp2tm1a(KOMP)Wtsi
Gene/Transgene symbolLcp2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d
Genetic informationThis mouse line originates from KOMP ES clone EPD0396_3_B12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal lens morphology / IMPC
  • cataract / IMPC
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • abnormal T cell activation / MGI
  • autoimmune response / MGI
  • abnormal T cell differentiation / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal double-positive T cell morphology / MGI
  • abnormal effector T cell morphology / MGI
  • abnormal T cell physiology / MGI
  • increased IgG level / MGI
  • increased IgE level / MGI
  • abnormal thymocyte activation / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal negative T cell selection / MGI
  • abnormal positive T cell selection / MGI
  • decreased T cell number / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased double-negative T cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal platelet activation / MGI
  • decreased NK T cell number / MGI
  • increased NK cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased single-positive T cell number / MGI
  • lymph node hypoplasia / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased platelet aggregation / MGI
  • abnormal NK cell physiology / MGI
  • perinatal lethality, incomplete penetrance / MGI

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Availabilities

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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