B6NJ;B6N-Cbltm1a(EUCOMM)Hmgu/CipheOrl

Status

Available to order

EMMA IDEM:08308
Citation informationRRID:IMSR_EM:08308 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6NJ;B6N-Cbltm1a(EUCOMM)Hmgu/CipheOrl
Alternative nameHEPD0672_6_B06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCbltm1a(EUCOMM)Hmgu
Gene/Transgene symbolCbl
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0672_6_B06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • prolonged PR interval / IMPC
  • thick ventricular wall / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
  • extramedullary hematopoiesis / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • enlarged lymph nodes / MGI
  • abnormal thymus morphology / MGI
  • dilated uterus / MGI
  • increased body weight / MGI
  • decreased body weight / MGI
  • hyperactivity / MGI
  • polyphagia / MGI
  • decreased brown adipose tissue amount / MGI
  • decreased white adipose tissue amount / MGI
  • thymus hypoplasia / MGI
  • abnormal T cell activation / MGI
  • abnormal glucose homeostasis / MGI
  • postnatal lethality / MGI
  • abnormal muscle physiology / MGI
  • abnormal lipid homeostasis / MGI
  • abnormal T cell differentiation / MGI
  • abnormal thymus size / MGI
  • abnormal bone marrow cell morphology/development / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal myeloblast morphology/development / MGI
  • abnormal T cell physiology / MGI
  • decreased circulating triglyceride level / MGI
  • decreased circulating free fatty acid level / MGI
  • decreased circulating insulin level / MGI
  • increased insulin sensitivity / MGI
  • abnormal gas homeostasis / MGI
  • increased lean body mass / MGI
  • increased hematopoietic stem cell number / MGI
  • increased oxygen consumption / MGI
  • improved glucose tolerance / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • skeleton phenotype / MGI
  • darkened coat color / MGI
  • abnormal food intake / MGI
  • thrombocytosis / MGI
  • increased body temperature / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • increased susceptibility to diet-induced obesity / MGI
  • decreased susceptibility to diet-induced obesity / MGI
  • decreased circulating leptin level / MGI
  • abnormal epididymal fat pad morphology / MGI
  • decreased single-positive T cell number / MGI
  • increased spleen red pulp amount / MGI
  • abnormal splenic cell ratio / MGI
  • abnormal thymus cell ratio / MGI
  • abnormal lymph node cell ratio / MGI
  • abnormal mammary fat pad morphology / MGI
  • dilated oviduct / MGI
  • abnormal fat cell morphology / MGI
  • decreased liver triglyceride level / MGI
  • abnormal foot pigmentation / MGI
  • decreased total body fat amount / MGI
  • myeloid hyperplasia / MGI
  • decreased respiratory quotient / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • increased tail pigmentation / MGI
  • increased ear pigmentation / MGI
  • increased mitochondria size / MGI
  • increased muscle cell glucose uptake / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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