B6;129S6-Casp1tm1a(EUCOMM)Wtsi/Oulu
| Status | Available to order |
| EMMA ID | EM:08376 |
| International strain name | B6;129S6-Casp1tm1a(EUCOMM)Wtsi/Oulu |
| Alternative name | Casp1 knock-out |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Casp1tm1a(EUCOMM)Wtsi, |
| Gene/Transgene symbol | Casp1 |
Information from provider
| Provider | Mohamed Lamkanfi |
| Provider affiliation | Dept. of Medical Protein Research, VIB/Ghent University, Faculty of Medicine and Health Sciences |
| Genetic information | The IKMC knock-out first targeting construct PG00146_Z_4_C11 was introduced into C57BL/6NCrl (male) x 129S6/SvEvTac (female) hybrid ES cells. Correct targeting was verified by PCR and Southern blotting. Chimeras were bred with C57BL/6OlaHsd mice and sperm was obtained from pups in the same background. In IVF, C57BL/6OlaHsd females were used as oocyte donors. |
| Phenotypic information | Homozygous:Not analyzedHeterozygous:viable |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd, wild-type C57BL/6JOlaHsd |
| Stage of embryos | 2-cell |
Literature references
- Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation.;Van Gorp Hanne, Saavedra Pedro H V, de Vasconcelos Nathalia M, Van Opdenbosch Nina, Vande Walle Lieselotte, Matusiak Magdalena, Prencipe Giusi, Insalaco Antonella, Van Hauwermeiren Filip, Demon Dieter, Bogaert Delfien J, Dullaers Melissa, De Baere Elfride, Hochepied Tino, Dehoorne Joke, Vermaelen Karim Y, Haerynck Filomeen, De Benedetti Fabrizio, Lamkanfi Mohamed, ;2016;Proceedings of the National Academy of Sciences of the United States of America;113;14384-14389; 27911804