C57BL/6N-Lyntm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:08396
Citation informationRRID:IMSR_EM:08396 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Lyntm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0704_6_B11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLyntm1a(EUCOMM)Hmgu
Gene/Transgene symbolLyn
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0704_6_B11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased mean platelet volume / IMPC
  • increased spleen weight / IMPC
  • decreased leukocyte cell number / IMPC
  • enlarged spleen / IMPC
  • decreased circulating cholesterol level / IMPC
  • thrombocytopenia / IMPC
  • abnormal gait / IMPC
  • increased blood urea nitrogen level / IMPC
  • increased monocyte cell number / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased hematocrit / IMPC
  • increased red blood cell distribution width / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased bone mineral density / IMPC
  • increased eosinophil cell number / IMPC
  • abnormal retina morphology / IMPC
  • increased neutrophil cell number / IMPC
  • abnormal maxilla morphology / IMPC
  • small thymus / IMPC
  • decreased hemoglobin content / IMPC
MGI phenotypes (gene matching)
  • increased neutrophil cell number / MGI
  • extramedullary hematopoiesis / MGI
  • increased mast cell number / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • spleen hyperplasia / MGI
  • spleen hypoplasia / MGI
  • enlarged lymph nodes / MGI
  • anemia / MGI
  • abnormal myelopoiesis / MGI
  • impaired hematopoiesis / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • abnormal inflammatory response / MGI
  • liver inflammation / MGI
  • premature death / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal proerythroblast morphology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal B cell physiology / MGI
  • increased immunoglobulin level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • increased IgE level / MGI
  • increased basophil cell number / MGI
  • glomerulonephritis / MGI
  • albuminuria / MGI
  • increased erythroid progenitor cell number / MGI
  • thrombocytopenia / MGI
  • peritoneal inflammation / MGI
  • abnormal microglial cell physiology / MGI
  • increased autoantibody level / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • abnormal class switch recombination / MGI
  • abnormal B cell morphology / MGI
  • decreased spleen weight / MGI
  • increased B-1 B cell number / MGI
  • decreased B-1 B cell number / MGI
  • increased T cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • abnormal level of surface class II molecules / MGI
  • decreased B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • glomerulosclerosis / MGI
  • increased macrophage cell number / MGI
  • increased plasma cell number / MGI
  • increased dendritic cell number / MGI
  • small Peyer's patches / MGI
  • decreased follicular B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • decreased spleen red pulp amount / MGI
  • increased spleen white pulp amount / MGI
  • decreased spleen white pulp amount / MGI
  • increased IgG1 level / MGI
  • increased IgG2b level / MGI
  • increased circulating interferon-gamma level / MGI
  • increased circulating interleukin-6 level / MGI
  • increased circulating interleukin-17 level / MGI
  • increased circulating interleukin-12 level / MGI
  • abnormal chemokine level / MGI
  • abnormal circulating chemokine level / MGI
  • abnormal circulating cytokine level / MGI
  • abnormal circulating complement protein level / MGI
  • myeloid hyperplasia / MGI
  • renal glomerulus hypertrophy / MGI
  • mesangial cell interposition / MGI
  • impaired humoral immune response / MGI
  • renal glomerular protein deposits / MGI
  • renal glomerular immunoglobulin deposits / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).