B6.129-Prdm1tm2.1Liz/RobH

Status

Available to order

EMMA IDEM:08439
International strain nameB6.129-Prdm1tm2.1Liz/RobH
Alternative namePrdm1 ΔEx1B/ΔEx1B(Rob)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPrdm1tm2.1Liz
Gene/Transgene symbolPrdm1

Information from provider

ProviderElizabeth Robertson
Provider affiliationThe Sir William Dunn School of Pathology, University of Oxford
Genetic informationA targeted deletion of a 3.9kb fragment from Prdm1 (chromosome 10: 44,247,021 to 44,250,926) containing the transcript exon 1B, a novel alternative first exon that splices directly to exon 3. This deletion generated an exon 1B null allele.
Phenotypic informationHomozygous:
Mice with targeted exon 1B deletion have slightly decreased expression in the yolk sac but show no other noticeable effects in embryo or adult tissues.

Heterozygous:
No phenotype.
Breeding historyExact number of generations backcrossed is unknown, but is more than 10. Exact number of generations sib-mated is unknown, but is more than 10 as, after backcrossing, they were maintained by intercrossing. Currently maintained as homozygous stock.
References
  • Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.;Morgan Marc A J, Magnusdottir Erna, Kuo Tracy C, Tunyaplin Chai, Harper James, Arnold Sebastian J, Calame Kathryn, Robertson Elizabeth J, Bikoff Elizabeth K, ;2009;Molecular and cellular biology;29;5813-27; 19737919
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal embryo size / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal heart morphology / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (allele matching)
  • immune system phenotype / MGI
MGI phenotypes (gene matching)
  • double outlet right ventricle / MGI
  • oligodactyly / MGI
  • abnormal myotome development / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • abnormal placenta morphology / MGI
  • abnormal placenta development / MGI
  • decreased trophoblast giant cell number / MGI
  • abnormal placenta labyrinth morphology / MGI
  • hemorrhage / MGI
  • no abnormal phenotype detected / MGI
  • abnormal germ cell morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • abnormal primordial germ cell migration / MGI
  • no phenotypic analysis / MGI
  • embryonic growth retardation / MGI
  • right aortic arch / MGI
  • abnormal dermomyotome development / MGI
  • abnormal spongiotrophoblast layer morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • absent oocytes / MGI
  • decreased testis weight / MGI
  • uterine hemorrhage / MGI
  • azoospermia / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal third pharyngeal arch morphology / MGI
  • absent second pharyngeal arch / MGI
  • absent plasma cells / MGI
  • decreased primordial germ cell number / MGI
  • absent primordial germ cells / MGI
  • abnormal splenocyte physiology / MGI
  • atrioventricular septal defect / MGI
  • vascular ring / MGI
  • abnormal left subclavian artery morphology / MGI
  • absent third pharyngeal arch / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal pharyngeal arch mesenchyme morphology / MGI

Literature references

  • Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.;Morgan Marc A J, Magnusdottir Erna, Kuo Tracy C, Tunyaplin Chai, Harper James, Arnold Sebastian J, Calame Kathryn, Robertson Elizabeth J, Bikoff Elizabeth K, ;2009;Molecular and cellular biology;29;5813-27; 19737919

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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