C57BL/6N-Atm1Brd Traf6tm2a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:08446
International strain nameC57BL/6N-Atm1Brd Traf6tm2a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0530_9_H08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTraf6tm2a(EUCOMM)Wtsi,
Gene/Transgene symbolTraf6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0530_9_H08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • decreased monocyte cell number / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • decreased Ly6C high monocyte number / IMPC
MGI phenotypes (allele matching)
  • abnormal forebrain morphology / MGI
  • abnormal olfactory bulb morphology / MGI
  • exencephaly / MGI
  • abnormal kidney morphology / MGI
  • abnormal brain morphology / MGI
  • abnormal brain commissure morphology / MGI
  • dilated bile duct / MGI
  • intestinal/bowel diverticulum / MGI
  • bifid ureter / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal Mullerian duct morphology / MGI
  • abnormal Wolffian duct morphology / MGI
  • abnormal myocardium compact layer morphology / MGI
  • abnormal optic stalk morphology / MGI
  • abnormal optic cup morphology / MGI
  • absent stapedial artery / MGI
  • abnormal stapes morphology / MGI
  • perimembraneous ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • persistent right dorsal aorta / MGI
  • herniated liver / MGI
  • umbilical vein stenosis / MGI
  • thin hypoglossal nerve / MGI
  • ductus venosus stenosis / MGI
  • subcutaneous edema / MGI
  • absent ductus venosus valve / MGI
  • abnormal ductus venosus valve topology / MGI
  • persistent right 6th pharyngeal arch artery / MGI
  • abnormal endolymphatic sac topology / MGI
  • multiple persisting craniopharyngeal ducts / MGI
  • blood in lymph vessels / MGI
  • abnormal coronary sinus connection / MGI
  • abnormal vitelline vein topology / MGI
  • abnormal vertebral artery topology / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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