IMPC phenotypes (gene matching)
C57BL/6N-Prkg1tm1a(KOMP)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:08524 |
| Citation information | RRID:IMSR_EM:08524 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Prkg1tm1a(KOMP)Wtsi/H |
| Alternative name | EPD0553_5_B04 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Prkg1tm1a(KOMP)Wtsi |
| Gene/Transgene symbol | Prkg1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from KOMP ES clone EPD0553_5_B04. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thoracic aortic aneurysm and aortic dissection / Orphanet_91387
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- abnormal systemic arterial blood pressure / MGI
- hypertension / MGI
- abnormal blood vessel physiology / MGI
- abnormal intestine morphology / MGI
- enlarged spleen / MGI
- impaired smooth muscle contractility / MGI
- abnormal penile erection / MGI
- anemia / MGI
- decreased brown adipose tissue amount / MGI
- reduced male fertility / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal erythrocyte morphology / MGI
- increased mean corpuscular volume / MGI
- reticulocytosis / MGI
- increased systemic arterial blood pressure / MGI
- decreased erythrocyte cell number / MGI
- abnormal cardiac muscle contractility / MGI
- impaired muscle relaxation / MGI
- abnormal intestinal peristalsis / MGI
- pyloric stenosis / MGI
- decreased cardiac output / MGI
- abnormal cardiac muscle relaxation / MGI
- salt-resistant hypertension / MGI
- increased mean systemic arterial blood pressure / MGI
- decreased triglyceride level / MGI
- renal/urinary system phenotype / MGI
- abnormal circulating hormone level / MGI
- increased mean corpuscular hemoglobin / MGI
- decreased vasodilation / MGI
- abnormal vascular smooth muscle physiology / MGI
- abnormal intestinal transit time / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- decreased brown fat cell lipid droplet size / MGI
- increased erythrocyte clearance / MGI
- increased red blood cell distribution width / MGI
- pyloric sphincter hypertrophy / MGI
- stomach fundus hypertrophy / MGI
- decreased body surface temperature / MGI
- postnatal lethality, complete penetrance / MGI
- abnormal adipose tissue development / MGI
- decreased mitochondrial DNA content / MGI
- abnormal brown adipose tissue thermogenesis / MGI