- decreased bone mineral density / IMPC
- abnormal head morphology / IMPC
- abnormal cranium morphology / IMPC
- abnormal maxilla morphology / IMPC
- abnormal stomach morphology / IMPC
- abnormal tibia morphology / IMPC
- abnormal autopod morphology / IMPC
- abnormal nail morphology / IMPC
- abnormal spleen morphology / IMPC
- decreased body length / IMPC
- abnormal lens morphology / IMPC
- cataract / IMPC
- hypoactivity / IMPC
- decreased startle reflex / IMPC
- abnormal vocalization / IMPC
- increased circulating HDL cholesterol level / IMPC
- abnormal motor capabilities/coordination/movement / IMPC
- abnormal eye morphology / IMPC
- abnormal digit morphology / IMPC
- abnormal tail morphology / IMPC
- brachydactyly / IMPC
- decreased circulating insulin level / IMPC
- short tibia / IMPC
- abnormal joint morphology / IMPC
- abnormal bone structure / IMPC
- abnormal heart left ventricle morphology / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- abnormal spine curvature / IMPC
- vertebral fusion / IMPC
- fusion of vertebral arches / IMPC
- abnormal behavior / IMPC
- decreased circulating glucose level / IMPC
- increased blood urea nitrogen level / IMPC
- abnormal optic disk morphology / IMPC
- increased circulating amylase level / IMPC
- decreased total body fat amount / IMPC
- increased grip strength / IMPC
- decreased grip strength / IMPC
- decreased bone mineral content / IMPC
- decreased food intake / IMPC
- increased fasted circulating glucose level / IMPC
C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/WtsiH
Status | Available to order |
EMMA ID | EM:08574 |
International strain name | C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/WtsiH |
Alternative name | EPD0296_2_A10 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Dnase1l2tm1.1(KOMP)Wtsi |
Gene/Transgene symbol | Dnase1l2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0296_2_A10. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (allele matching)
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