C57BL/6N-Zfp106tm1c(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:09050
Citation informationRRID:IMSR_EM:09050 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Zfp106tm1c(KOMP)Wtsi/H
Alternative nameEPD0033_4_C03
Strain typeTargeted Mutant Strains : Targeted Conditional
Allele/Transgene symbolZfp106tm1c(KOMP)Wtsi
Gene/Transgene symbolZfp106
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis line originates from KOMP ES clone EPD0033_4_C03, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IKMC page on the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating calcium level / IMPC
  • abnormal external female genitalia morphology / IMPC
  • increased thermal nociceptive threshold / IMPC
  • decreased body weight / IMPC
  • abnormal gait / IMPC
  • abnormal posture / IMPC
MGI phenotypes (gene matching)
  • kyphosis / MGI
  • increased circulating calcium level / MGI
  • tremors / MGI
  • abnormal skeletal muscle morphology / MGI
  • motor neuron degeneration / MGI
  • decreased motor neuron number / MGI
  • abnormal spinal cord morphology / MGI
  • small dorsal root ganglion / MGI
  • small L4 dorsal root ganglion / MGI
  • small L5 dorsal root ganglion / MGI
  • weight loss / MGI
  • hypoactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • limb grasping / MGI
  • impaired limb coordination / MGI
  • premature death / MGI
  • abnormal muscle physiology / MGI
  • gliosis / MGI
  • neurodegeneration / MGI
  • chromatolysis / MGI
  • abnormal soleus morphology / MGI
  • abnormal gastrocnemius morphology / MGI
  • abnormal redox activity / MGI
  • astrocytosis / MGI
  • nervous system phenotype / MGI
  • abnormal muscle electrophysiology / MGI
  • abnormal physical strength / MGI
  • cachexia / MGI
  • positive geotaxis / MGI
  • abnormal axon morphology / MGI
  • axon degeneration / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal lumbar dorsal root ganglion morphology / MGI
  • microgliosis / MGI
  • abnormal external male genitalia morphology / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • decreased skeletal muscle fiber number / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • skeletal muscle fiber degeneration / MGI
  • skeletal muscle fiber atrophy / MGI
  • skeletal muscle atrophy / MGI
  • skeletal muscle fibrosis / MGI
  • decreased gastrocnemius weight / MGI
  • decreased soleus weight / MGI
  • decreased tibialis anterior weight / MGI
  • decreased grip strength / MGI
  • abnormal mitochondrial ATP synthesis coupled electron transport / MGI
  • increased spinal cord apoptosis / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
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