IMPC phenotypes (gene matching)
C57BL/6-Atm1Brd Lpar1tm1a(EUCOMM)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:09092 |
| Citation information | RRID:IMSR_EM:09092 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Atm1Brd Lpar1tm1a(EUCOMM)Wtsi/Flmg |
| Alternative name | B6-Lpar1 tm1a(EUCOMM)Wtsi/Flmg |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Lpar1tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lpar1 |
Information from provider
| Provider | Vassilis Aidinis |
| Provider affiliation | BSRC Al. Fleming |
| Additional owner | contact Kay Martin |
| Genetic information | Mouse line originated from EUCOMM clone EPD0496_2_C05 injected into B6 albino blastocysts. |
| Phenotypic information | Homozygous:Not knownHeterozygous:No overt phenotype in heterozygous knock-out animals. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal craniofacial morphology / MGI
- short snout / MGI
- exencephaly / MGI
- abnormal Schwann cell morphology / MGI
- decreased Schwann cell number / MGI
- decreased body height / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ocular hypertelorism / MGI
- hypoactivity / MGI
- abnormal suckling behavior / MGI
- postnatal growth retardation / MGI
- increased dopamine level / MGI
- hemorrhage / MGI
- abnormal sciatic nerve morphology / MGI
- nervous system phenotype / MGI
- long incisors / MGI
- abnormal serotonin level / MGI
- abnormal amino acid level / MGI
- decreased body mass index / MGI
- decreased prepulse inhibition / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- decreased body fat mass / MGI
Literature references
- Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.;Ray Rashmi, Sinha Sunita, Aidinis Vassilis, Rai Vivek, ;2021;Cell reports;34;108809; 33657371