- increased bone mineral density / IMPC
- kyphosis / IMPC
- decreased circulating LDL cholesterol level / IMPC
- decreased circulating HDL cholesterol level / IMPC
- decreased hematocrit / IMPC
- enlarged heart / IMPC
- abnormal spleen morphology / IMPC
- enlarged spleen / IMPC
- decreased body length / IMPC
- anophthalmia / IMPC
- hypoactivity / IMPC
- decreased caudal vertebrae number / IMPC
- decreased mean corpuscular volume / IMPC
- increased mean platelet volume / IMPC
- abnormal retinal vasculature morphology / IMPC
- decreased hemoglobin content / IMPC
- decreased erythrocyte cell number / IMPC
- decreased lean body mass / IMPC
- decreased circulating iron level / IMPC
- abnormal spine curvature / IMPC
- abnormal behavior / IMPC
- increased spleen weight / IMPC
- decreased circulating cholesterol level / IMPC
- impaired glucose tolerance / IMPC
- increased circulating bilirubin level / IMPC
- decreased mean corpuscular hemoglobin / IMPC
- decreased mean corpuscular hemoglobin concentration / IMPC
- increased glycosylated hemoglobin level / IMPC
- decreased circulating amylase level / IMPC
- decreased total body fat amount / IMPC
- increased grip strength / IMPC
- increased red blood cell distribution width / IMPC
- abnormal retinal blood vessel morphology / IMPC
- shortened RR interval / IMPC
- preweaning lethality, incomplete penetrance / IMPC
- increased fluid intake / IMPC
- decreased total retina thickness / IMPC
- increased memory-marker gamma-delta T cell number / IMPC
- increased memory-marker CD4-negative NK T cell number / IMPC
C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg
Status | Available to order |
EMMA ID | EM:09105 |
International strain name | C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Ieg |
Alternative name | EPD0033_3_C09 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Prkab1tm1b(KOMP)Wtsi, |
Gene/Transgene symbol | Prkab1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
Genetic information | This mouse line originates from KOMP ES clone EPD0033_3_C09. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele (Gt(ROSA)26Sor |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6NTac |
Disease and phenotype information
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased hematocrit / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- echinocytosis / MGI
- schistocytosis / MGI
- enlarged spleen / MGI
- hemolytic anemia / MGI
- abnormal bone marrow morphology / MGI
- abnormal erythrocyte morphology / MGI
- increased mean platelet volume / MGI
- reticulocytosis / MGI
- anisocytosis / MGI
- microcytic anemia / MGI
- microcytosis / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- increased erythroid progenitor cell number / MGI
- abnormal erythrocyte osmotic lysis / MGI
- decreased circulating iron level / MGI
- increased spleen weight / MGI
- decreased mean corpuscular hemoglobin concentration / MGI
- increased spleen red pulp amount / MGI
- increased spleen iron level / MGI
- increased red blood cell distribution width / MGI
- stomatocytosis / MGI
- acanthocytosis / MGI
- increased erythroblast number / MGI
- increased circulating erythropoietin level / MGI
- increased circulating ferritin level / MGI
- abnormal reticulocyte cell number / MGI
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