C57BL/6N-Atm1Brd Atf2tm1a(EUCOMM)Hmgu/Ph

Status

Available to order

EMMA IDEM:09148
Citation informationRRID:IMSR_EM:09148 

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International strain nameC57BL/6N-Atm1Brd Atf2tm1a(EUCOMM)Hmgu/Ph
Alternative nameB6.Atf2tm1a
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAtf2tm1a(EUCOMM)Hmgu
Gene/Transgene symbolAtf2

Information from provider

ProviderRegine Schneider-Stock
Provider affiliationPathologisches Institut , Universitätsklinikum Erlangen
Genetic informationAtf2 gene was conditionally targeted by insertion of a reporter-tagged cassette containing lacZ, neomycin resistance, Frt and LoxP sequences. Exons 6-7 were targeted by homologous recombination and electroporation of the targeting construct into C57BL/6N-A/a ES cells. The targeting resulted in a so called "knockout-first allele". LacZ and neomycin cassettes together are flanked by Frt sites; neomycin cassette and targeted exons 6-7 are flanked by LoxP sites. Positive targeted ES cell clones were injected into C57BL/6N embryos.
Phenotypic informationHomozygous:
The strain was not bred for homozygous mice. Phenotype unknown.

Heterozygous:
Heterozygous mice appear normal like wild-type animals. No obvious phenotype.
Breeding historyChimeric mice were paired with wild-type C57BL/6N partners to test for germ-line transmission and to obtain heterozygous F1 generation mice.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic
Animals used for archivingheterozygous C57BL/6NCrl males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased circulating chloride level / IMPC
  • abnormal kidney morphology / IMPC
  • abnormal urinary bladder morphology / IMPC
  • abnormal spleen morphology / IMPC
  • small testis / IMPC
  • abnormal heart morphology / IMPC
  • decreased thigmotaxis / IMPC
  • decreased body weight / IMPC
  • increased lung elastance / IMPC
  • increased blood urea nitrogen level / IMPC
  • abnormal testis morphology / IMPC
  • abnormal skin morphology / IMPC
  • enlarged heart / IMPC
  • decreased mean platelet volume / IMPC
  • increased fasting circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • abnormal chondrocyte morphology / MGI
  • short limbs / MGI
  • tremors / MGI
  • decreased brain size / MGI
  • decreased Purkinje cell number / MGI
  • ectopic Purkinje cell / MGI
  • abnormal lung morphology / MGI
  • decreased body weight / MGI
  • increased metastatic potential / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • impaired limb coordination / MGI
  • cyanosis / MGI
  • abnormal placenta labyrinth morphology / MGI
  • eye inflammation / MGI
  • respiratory failure / MGI
  • postnatal lethality / MGI
  • no abnormal phenotype detected / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • chondrodystrophy / MGI
  • head shaking / MGI
  • abnormal vestibular ganglion morphology / MGI
  • abnormal cytokine secretion / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • decreased otolith number / MGI
  • abnormal placenta vasculature / MGI
  • abnormal artery development / MGI
  • decreased vestibular hair cell number / MGI
  • abnormal vestibular saccular macula morphology / MGI
  • abnormal utricular macula morphology / MGI
  • decreased vestibular hair cell stereocilia number / MGI
  • hypoxia / MGI
  • head tossing / MGI
  • immune system phenotype / MGI
  • impaired hearing / MGI
  • decreased long bone epiphyseal plate size / MGI
  • disorganized long bone epiphyseal plate / MGI
  • decreased NK T cell number / MGI
  • decreased NK cell number / MGI
  • decreased circulating interferon-gamma level / MGI
  • increased susceptibility to endotoxin shock / MGI
  • proportional dwarf / MGI
  • abnormal NK cell physiology / MGI
  • lethality at weaning, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, complete penetrance / MGI
  • enlarged brain ventricles / MGI

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