STOCK Samd8tm2.1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:09173 |
International strain name | STOCK Samd8tm2.1Kwi/Cnrm |
Alternative name | B6N;129P2-SMSrtm11Kwi/Cnrm |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Samd8tm2.1Kwi, |
Gene/Transgene symbol | Samd8 |
Information from provider
Provider | Klaus Willecke |
Provider affiliation | Molecular Genetics, Limes Institute |
Genetic information | Smsr (Samd8) flox: catalytically active exon 6 is floxed; cre recombinase-mediated recombination leads to production of Smsr protein lacking carboxy-terminus; cre-mediated recombination leads to the production of a catalytically inactive Smsr-eGFP fusion protein. |
Phenotypic information | Homozygous:Fertile with no obvious phenotypic abnormalitiesHeterozygous:Fertile with no obvious phenotypic abnormalities |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis.;Tafesse Fikadu G, Vacaru Ana M, Bosma Elleke F, Hermansson Martin, Jain Amrita, Hilderink Angelika, Somerharju Pentti, Holthuis Joost C M, ;2014;Journal of cell science;127;445-54; 24259670
- Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER.;Vacaru Ana M, Tafesse Fikadu G, Ternes Philipp, Kondylis Vangelis, Hermansson Martin, Brouwers Jos F H M, Somerharju Pentti, Rabouille Catherine, Holthuis Joost C M, ;2009;The Journal of cell biology;185;1013-27; 19506037
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