STOCK Nub1tm1a(EUCOMM)Hmgu/Ph

Status

Available to order

EMMA IDEM:09373
Citation informationRRID:IMSR_EM:09373 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Nub1tm1a(EUCOMM)Hmgu/Ph
Alternative nameHEPD0664_6_C08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNub1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolNub1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0664_6_C08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal optic disk morphology / IMPC
  • decreased CD4-positive, alpha-beta T cell number / IMPC
  • increased freezing behavior / IMPC
  • abnormal spleen morphology / IMPC
  • immune system phenotype / IMPC
  • decreased Ly6C-positive NK T cell number / IMPC
  • decreased circulating iron level / IMPC
  • increased heart atrium size / IMPC
  • abnormal retina morphology / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • increased Ly6C-positive NK T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased NK T cell number / IMPC
  • decreased CD4-negative NK T cell number / IMPC
  • abnormal lens morphology / IMPC
  • enlarged spleen / IMPC
  • decreased CD5-positive Ly6C-positive T cell number / IMPC
  • increased effector memory T-helper cell number / IMPC
  • abnormal heart morphology / IMPC
  • increased circulating potassium level / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased NK cell number / IMPC
  • decreased CD11b-high dendritic cell number / IMPC

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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