C57BL/6N-Notch1tm1a(EUCOMM)Hmgu/H
Status | Available to order |
EMMA ID | EM:09421 |
Citation information | RRID:IMSR_EM:09421 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Notch1tm1a(EUCOMM)Hmgu/H |
Alternative name | HEPD0627_7_B12 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Notch1tm1a(EUCOMM)Hmgu |
Gene/Transgene symbol | Notch1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from EUCOMM ES clone HEPD0627_7_B12. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Adams-Oliver syndrome / Orphanet_974
- Familial bicuspid aortic valve / Orphanet_402075
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal vertebrae morphology / MGI
- abnormal vascular development / MGI
- abnormal heart development / MGI
- distended pericardium / MGI
- trabecula carnea hypoplasia / MGI
- abnormal cell death / MGI
- decreased thymocyte number / MGI
- abnormal trigeminal ganglion morphology / MGI
- anemia / MGI
- abnormal vasculogenesis / MGI
- abnormal somite development / MGI
- decreased embryo size / MGI
- absent vitelline blood vessels / MGI
- pale yolk sac / MGI
- embryonic growth arrest / MGI
- postnatal growth retardation / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- disorganized myocardium / MGI
- abnormal artery morphology / MGI
- abnormal placenta vasculature / MGI
- kinked neural tube / MGI
- delayed somite formation / MGI
- abnormal nervous system development / MGI
- embryonic growth retardation / MGI
- abnormal embryonic neuroepithelium morphology / MGI
- increased cochlear outer hair cell number / MGI
- notochord degeneration / MGI
- abnormal dorsal aorta morphology / MGI
- decreased T cell number / MGI
- decreased double-negative T cell number / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal somite size / MGI
- abnormal left-right axis symmetry of the somites / MGI
- abnormal myocardium layer morphology / MGI
- decreased angiogenesis / MGI
- embryonic lethality during organogenesis / MGI
- small pharyngeal arch / MGI
- increased T cell apoptosis / MGI
- embryonic lethality / MGI
- abnormal cardiac epithelial to mesenchymal transition / MGI
- abnormal retinal blood vessel morphology / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
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