C57BL/6N-Atm1Brd Duoxa2tm1a(KOMP)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:09460
Citation informationRRID:IMSR_EM:09460 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Duoxa2tm1a(KOMP)Wtsi/WtsiOrl
Alternative nameEPD0899_5_A06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDuoxa2tm1a(KOMP)Wtsi
Gene/Transgene symbolDuoxa2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0899_5_A06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased circulating calcium level / IMPC
  • decreased bone mineral density / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal radius morphology / IMPC
  • increased circulating cholesterol level / IMPC
  • decreased bone mineral content / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • decreased grip strength / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • abnormal tibia morphology / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • decreased leukocyte cell number / IMPC
  • increased circulating creatinine level / IMPC
  • abnormal clavicle morphology / IMPC
  • abnormal hair growth / IMPC
  • abnormal joint morphology / IMPC
  • increased circulating fructosamine level / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • abnormal thoracic cage shape / IMPC
  • decreased Ly6C low monocyte number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • increased lean body mass / IMPC
  • decreased lean body mass / IMPC
  • abnormal vertebral arch morphology / IMPC
  • decreased mature B cell number / IMPC
  • decreased red blood cell distribution width / IMPC
  • increased T cell number / IMPC
  • decreased immature B cell number / IMPC
  • decreased memory-marker gamma-delta T cell number / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased hematocrit / IMPC
  • abnormal femur morphology / IMPC
  • increased circulating iron level / IMPC
  • increased alpha-beta T cell number / IMPC
  • decreased circulating glucose level / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal vertebrae morphology / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased circulating sodium level / IMPC
  • increased circulating LDL cholesterol level / IMPC
  • abnormal humerus morphology / IMPC
  • increased total body fat amount / IMPC
  • decreased B cell number / IMPC
  • increased circulating total protein level / IMPC
  • decreased B-2 B cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • increased neutrophil cell number / IMPC
  • absent pinna reflex / IMPC
  • increased circulating serum albumin level / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased transitional stage T1 B cell number / IMPC
  • decreased heart weight / IMPC
  • abnormal zygomatic bone morphology / IMPC
  • abnormal ulna morphology / IMPC
  • increased CD8-positive, naive alpha-beta T cell number / IMPC
  • decreased circulating thyroxine level / IMPC
  • increased plasmacytoid dendritic cell number / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • abnormal snout morphology / IMPC
  • abnormal cranium morphology / IMPC
  • decreased body length / IMPC
  • decreased hemoglobin content / IMPC
  • increased CD8-positive, alpha-beta T cell number / IMPC
  • abnormal bone structure / IMPC
  • decreased follicular B cell number / IMPC
  • decreased circulating amylase level / IMPC
  • increased T-helper cell number / IMPC
  • abnormal head morphology / IMPC
  • decreased total body fat amount / IMPC
  • improved glucose tolerance / IMPC
  • abnormal eyelid morphology / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal iris morphology / IMPC
  • decreased NK cell number / IMPC
  • decreased CD11b-high dendritic cell number / IMPC
  • decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased mean platelet volume / IMPC
MGI phenotypes (gene matching)
  • no abnormal phenotype detected / MGI

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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