C57BL/6NTac-Commd9tm1a(KOMP)Wtsi/H

Status

Available to order

EMMA IDEM:09482
Citation informationRRID:IMSR_EM:09482 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Commd9tm1a(KOMP)Wtsi/H
Alternative nameEPD0136_6_D11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCommd9tm1a(KOMP)Wtsi
Gene/Transgene symbolCommd9
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from KOMP ES clone EPD0136_6_D11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased red blood cell distribution width / IMPC
  • decreased locomotor activity / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • decreased circulating fructosamine level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased lymphocyte cell number / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased neutrophil cell number / IMPC
  • impaired glucose tolerance / IMPC
MGI phenotypes (gene matching)
  • abnormal cardiovascular system physiology / MGI
  • edema / MGI
  • hemorrhage / MGI
  • intracranial hemorrhage / MGI
  • intracerebral hemorrhage / MGI
  • abnormal neural tube morphology / MGI
  • abnormal vein morphology / MGI
  • heart hypoplasia / MGI
  • abnormal dorsal aorta morphology / MGI
  • dilated vasculature / MGI
  • hemopericardium / MGI
  • myocardial necrosis / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal cranial blood vasculature morphology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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