B6.Cg-Tg(RasE)290Biat/Biat
| Status | Available to order |
| EMMA ID | EM:09501 |
| Citation information | RRID:IMSR_EM:09501 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(RasE)290Biat/Biat |
| Alternative name | B6;D2-Tg(RasE)290Biat |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(RasE)290Biat |
| Gene/Transgene symbol | Tg(RasE)290Biat |
Information from provider
| Provider | Robert Eferl |
| Provider affiliation | Institute for Cancer Research (ICR), Medical University Vienna (MUV) |
| Additional owner | Prof. Thomas Ruelicke, Vetmeduni Vienna, Vienna, Austria |
| Genetic information | Transgenic line produced by pronucleus injection of a BAC transgene |
| Phenotypic information | Homozygous:The mice have no phenotype because there is no transgene expression per se. Three oncogenic H-RasV12 effector mutants are expressed in a stochastic manner when cre recombinase is induced. This will cause oncogenic transformation of cre-expressing cells and tumor formation.Heterozygous:no phenotype |
| Breeding history | Transgenic line was intercrossed several times and then backcrossed for 6 generations into C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Literature references
- A mouse model to identify cooperating signaling pathways in cancer.;Musteanu Monica, Blaas Leander, Zenz Rainer, Svinka Jasmin, Hoffmann Thomas, Grabner Beatrice, Schramek Daniel, Kantner Hans-Peter, Müller Mathias, Kolbe Thomas, Rülicke Thomas, Moriggl Richard, Kenner Lukas, Stoiber Dagmar, Penninger Josef Martin, Popper Helmut, Casanova Emilio, Eferl Robert, ;2012;Nature methods;9;897-900; 22863881