STOCK Men1tm1.2Zqw/Flmg

Status

Available to order

EMMA IDEM:09502
Citation informationRRID:IMSR_EM:09502 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Men1tm1.2Zqw/Flmg
Alternative nameMen1floxed/floxed
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolMen1tm1.2Zqw
Gene/Transgene symbolMen1

Information from provider

ProviderPhilippe Bertolino
Provider affiliationCancer Research Center of Lyon
Genetic informationMice carrying the homozygous floxed Men1 allele.
Phenotypic informationHomozygous:
No phenotype has been observed.

Heterozygous:
No phenotype has been observed.
References
  • Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.;Bertolino Philippe, Radovanovic Ivan, Casse Huguette, Aguzzi Adriano, Wang Zhao-Qi, Zhang Chang-Xian, ;2003;Mechanisms of development;120;549-60; 12782272
  • Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice.;Bertolino Philippe, Tong Wei-Min, Herrera Pedro Luis, Casse Huguette, Zhang Chang Xian, Wang Zhao-Qi, ;2003;Cancer research;63;4836-41; 12941803
  • Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.;Lu Jieli, Herrera Pedro L, Carreira Christine, Bonnavion Rémy, Seigne Christelle, Calender Alain, Bertolino Philippe, Zhang Chang Xian, ;2010;Gastroenterology;138;1954-65; 20138042
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archivinghomozygous mixed 129, C57BL/6 males, wild-type C57BL/6J females
Stage of embryosMorula

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • hypoglycemia / MGI
  • increased circulating calcium level / MGI
  • decreased circulating phosphate level / MGI
  • thin ventricular wall / MGI
  • trabecula carnea hypoplasia / MGI
  • delayed hepatic development / MGI
  • abnormal pituitary gland morphology / MGI
  • enlarged pituitary gland / MGI
  • enlarged adrenal glands / MGI
  • exencephaly / MGI
  • enlarged testis / MGI
  • Leydig cell hyperplasia / MGI
  • decreased embryo size / MGI
  • increased circulating corticosterone level / MGI
  • pancreas inflammation / MGI
  • hemorrhage / MGI
  • abnormal pancreas morphology / MGI
  • increased tumor incidence / MGI
  • increased lung adenocarcinoma incidence / MGI
  • increased adrenal gland tumor incidence / MGI
  • increased carcinoma incidence / MGI
  • increased pituitary adenoma incidence / MGI
  • increased pheochromocytoma incidence / MGI
  • increased circulating insulin level / MGI
  • premature death / MGI
  • abnormal embryonic tissue morphology / MGI
  • increased intestinal adenoma incidence / MGI
  • pancreas cysts / MGI
  • increased insulinoma incidence / MGI
  • increased glucagonoma incidence / MGI
  • increased pancreatic islet cell adenoma incidence / MGI
  • parathyroid gland hyperplasia / MGI
  • increased parathyroid adenoma incidence / MGI
  • increased thyroid adenoma incidence / MGI
  • thyroid gland hyperplasia / MGI
  • increased prolactinoma incidence / MGI
  • increased pancreatic beta cell number / MGI
  • abnormal neural tube closure / MGI
  • abnormal craniofacial development / MGI
  • embryonic growth retardation / MGI
  • enlarged ovary / MGI
  • abnormal cell differentiation / MGI
  • homeostasis/metabolism phenotype / MGI
  • pancreatic islet hyperplasia / MGI
  • increased testis tumor incidence / MGI
  • increased ovary tumor incidence / MGI
  • increased lung tumor incidence / MGI
  • increased pancreas adenoma incidence / MGI
  • increased adrenal gland adenoma incidence / MGI
  • abnormal pancreatic acinar cell morphology / MGI
  • pancreas necrosis / MGI
  • increased pancreas tumor incidence / MGI
  • increased gonad tumor incidence / MGI
  • increased Leydig cell tumor incidence / MGI
  • increased gastrointestinal tumor incidence / MGI
  • increased gland tumor incidence / MGI
  • increased mammary gland tumor incidence / MGI
  • increased stomach tumor incidence / MGI
  • increased thyroid tumor incidence / MGI
  • increased pituitary gland tumor incidence / MGI
  • increased parathyroid gland tumor incidence / MGI
  • increased thyroid carcinoma incidence / MGI
  • increased pancreatic islet cell carcinoma incidence / MGI
  • increased pituitary adenohypophysis tumor incidence / MGI
  • increased adrenal cortical tumor incidence / MGI
  • increased adrenocortical adenoma incidence / MGI
  • thin interventricular septum / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • thyroid cyst / MGI

Literature references

  • Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.;Bertolino Philippe, Radovanovic Ivan, Casse Huguette, Aguzzi Adriano, Wang Zhao-Qi, Zhang Chang-Xian, ;2003;Mechanisms of development;120;549-60; 12782272
  • Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice.;Bertolino Philippe, Tong Wei-Min, Herrera Pedro Luis, Casse Huguette, Zhang Chang Xian, Wang Zhao-Qi, ;2003;Cancer research;63;4836-41; 12941803
  • Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.;Lu Jieli, Herrera Pedro L, Carreira Christine, Bonnavion Rémy, Seigne Christelle, Calender Alain, Bertolino Philippe, Zhang Chang Xian, ;2010;Gastroenterology;138;1954-65; 20138042

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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