B6NCrl;B6N-A^tm1Brd Cdon^{tm1a(EUCOMM)Hmgu}/Orl

Status	Available to order
EMMA ID	EM:09568
Citation information	RRID:IMSR_EM:09568 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6NCrl;B6N-A^tm1Brd Cdon^{tm1a(EUCOMM)Hmgu}/Orl
Alternative name	HEPD0610_4_C03
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Cdon^{tm1a(EUCOMM)Hmgu}
Gene/Transgene symbol	Cdon
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Institut de Transgenose, INTRAGENE
Provider affiliation	TAAM-CDTA UPS44, Institut de Transgenose, INTRAGENE
Genetic information	This mouse line originates from EUCOMM ES clone HEPD0610_4_C03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France
Animals used for archiving	heterozygous C57BL/6NCrl males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Alobar holoprosencephaly / Orphanet_93925
Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
Microform holoprosencephaly / Orphanet_280200
Pituitary stalk interruption syndrome / Orphanet_95496
Septopreoptic holoprosencephaly / Orphanet_280195
Semilobar holoprosencephaly / Orphanet_220386
Lobar holoprosencephaly / Orphanet_93924

IMPC phenotypes (gene matching)

preweaning lethality, incomplete penetrance / IMPC

MGI phenotypes (gene matching)

abnormal craniofacial morphology / MGI
absent maxillary shelf / MGI
domed cranium / MGI
abnormal maxilla morphology / MGI
weakness / MGI
abnormal forebrain morphology / MGI
abnormal cerebral cortex morphology / MGI
abnormal brain ventricle morphology / MGI
decreased body size / MGI
abnormal blood vessel morphology / MGI
hydroencephaly / MGI
hemorrhage / MGI
premature death / MGI
abnormal nose morphology / MGI
abnormal premaxilla morphology / MGI
nervous system phenotype / MGI
abnormal craniofacial development / MGI
small basisphenoid bone / MGI
basisphenoid bone foramen / MGI
abnormal maxillary shelf morphology / MGI
absent upper incisors / MGI
abnormal neuronal precursor proliferation / MGI
holoprosencephaly / MGI
thin cerebral cortex / MGI
enlarged lateral ventricles / MGI
abnormal palate development / MGI
decreased maxillary shelf size / MGI
postnatal lethality, incomplete penetrance / MGI
neonatal lethality, incomplete penetrance / MGI
perinatal lethality, incomplete penetrance / MGI
abnormal philtrum morphology / MGI
absent lamina terminalis / MGI
abnormal upper incisor morphology / MGI
small nasal septum / MGI
absent nasal septum cartilage / MGI
nasal septum cartilage hypoplasia / MGI
piriform aperture stenosis / MGI
absent primary palate / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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