B6D2-Tg(KRT14-Pgf)1Odo/Cnrm
| Status | Available to order |
| EMMA ID | EM:09586 |
| International strain name | B6D2-Tg(KRT14-Pgf)1Odo/Cnrm |
| Alternative name | K14-PlGF |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-Pgf)1Odo, |
| Gene/Transgene symbol | Tg(KRT14-Pgf)1Odo |
Information from provider
| Provider | Teresa ODORISIO |
| Provider affiliation | Lab. Biologia Molecolare e Cellulare, Istituto Dermopatico dell'Immacolata |
| Genetic information | Transgenic mice overexpressing the full coding sequence of mouse placenta growth factor (PlGF) under the control of human keratin 14 promoter . |
| Phenotypic information | Homozygous:Homozygous mice were never obtained by crossing heterozygous mice.Heterozygous:Heterozygous transgenic mice manifest a strong increase in the number, branching and size of dermal blood vessels as well as enhanced vascular permeability. |
| Breeding history | For generating transgenic mice, fertilized oocytes were obtained from a (C57BL/6 x DBA/2) mouse cross. Transgenic lines were established on a B6D2F1 background, by crossing heterozygous mice (Tg/+) with B6D2F1 wt mice. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability.;Odorisio Teresa, Schietroma Cataldo, Zaccaria M Letizia, Cianfarani Francesca, Tiveron Cecilia, Tatangelo Laura, Failla Cristina M, Zambruno Giovanna, ;2002;Journal of cell science;115;2559-67; 12045226
- Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential.;Cianfarani Francesca, Zambruno Giovanna, Brogelli Laura, Sera Francesco, Lacal Pedro Miguel, Pesce Maurizio, Capogrossi Maurizio C, Failla Cristina Maria, Napolitano Monica, Odorisio Teresa, ;2006;The American journal of pathology;169;1167-82; 17003476
- Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.;Wirzenius Maria, Tammela Tuomas, Uutela Marko, He Yulong, Odorisio Teresa, Zambruno Giovanna, Nagy Janice A, Dvorak Harold F, Ylä-Herttuala Seppo, Shibuya Masabumi, Alitalo Kari, ;2007;The Journal of experimental medicine;204;1431-40; 17535974
- Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor.;Marcellini Marcella, De Luca Naomi, Riccioni Teresa, Ciucci Alessandro, Orecchia Angela, Lacal Pedro Miguel, Ruffini Federica, Pesce Maurizio, Cianfarani Francesca, Zambruno Giovanna, Orlandi Augusto, Failla Cristina Maria, ;2006;The American journal of pathology;169;643-54; 16877362